{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:57:54Z","timestamp":1784782674585,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multidrug\u2010resistant tuberculosis (MDR\u2010TB) deeply impacts the well\u2010being of adolescents and young adults (AYA), resulting in poor treatment adherence. Identifying psychosocial challenges and preferred interventions is essential to enhance treatment adherence and outcomes in this unique group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a mixed\u2010method study where participants aged between 15 and 24 years, diagnosed with MDR\u2010TB, were recruited for in\u2010depth interviews and a semi\u2010structured questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The individual\u2010level psychosocial challenges included mental stress, suicidal ideation, reluctance to continue medication, perceived and experienced stigma, and socio\u2010economic burdens. Health system\u2010related challenges encompassed delayed diagnosis, drug stockouts, and negative experiences with Health Care Providers (HCPs). Among 75 participants, the median age was 20.5 years, with 57% (\n                      <jats:italic>n<\/jats:italic>\n                      = 41) females, 85% (\n                      <jats:italic>n<\/jats:italic>\n                      = 62) single, and a median treatment duration of 8 months at the interview. Seventy\u2010two percent (\n                      <jats:italic>n<\/jats:italic>\n                      = 54) of the participants reported psychological issues such as irritation, loneliness, anxiety, sleep disorder, suicidal ideation, and stigma. Individual\u2010level interventions were preferred by 61% (\n                      <jats:italic>n<\/jats:italic>\n                      = 46) of participants, including social media, deep breathing, and exercise training.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To enhance results in MDR\u2010TB, it is crucial to develop and assess personalized psychosocial interventions with tailored adjustments to tackle the psychosocial obstacles encountered by adolescents and young adults with MDR\u2010TB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70665","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:23:55Z","timestamp":1754371435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improving Treatment Adherence in Youths With 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