{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:01:36Z","timestamp":1789156896706,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the role of sensory input in maintaining balance is well established, the effects of various auditory frequency stimulations, such as binaural beat stimulation (BBS), on patients with central nervous system injuries, particularly those who have experienced a stroke, remain inadequately understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized case\u2010control study compared the functional outcomes between patients with stroke undergoing BBS during rehabilitation training and those receiving traditional music therapies. The assessed primary outcomes included balance function, balance confidence, lower\u2010limb function, and activities of daily living, cognitive abilities, and depression scores. Subsequently, correlations between outcome parameters were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 27 patients with stroke completed the study protocol (BBS\n                      <jats:italic>n<\/jats:italic>\n                      = 15, control\n                      <jats:italic>n<\/jats:italic>\n                      = 12). Post\u2010intervention analyses revealed improvements in balance\u2010related indicators, particularly the scores of the Berg Balance Scale (BBSc) and Mini\u2010Balance Evaluation Systems Test (Mini\u2010BESTest), across both groups. However, the Barthel index (BI) and Beck depression inventory scores (BDIS) in the BBS group exhibited significantly greater improvements than those in the control group. Correlation analyses indicated that changes in balance\u2010related scores within the BBS group were associated with improvements in lower\u2010limb function, mood, and activities of daily living. Conversely, the control group observed correlations among the internal components of the balance\u2010related scales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Appropriate BBS stimulation appears to enhance balance, likely owing to the synergistic effects of music and rhythm. Further research focusing on brain function is necessary to elucidate the mechanisms underlying the therapeutic efficacy of BBS interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70671","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:28:22Z","timestamp":1751866102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Auditory Frequency Stimulation on Balance and Rehabilitation Outcomes in Patients With Stroke: A Randomized Case\u2010Control Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Ruijin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Therapy Second Affiliated Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-8815","authenticated-orcid":false,"given":"Lihua","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Therapy Second Affiliated Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juchuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2014.11.029"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035740"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1197733"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203805299"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092638"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.178002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00140139.2016.1182649"},{"issue":"10","key":"e_1_2_12_9_1","article-title":"Impact of Music Therapy on Gait After Stroke","volume":"13","author":"Daniel A.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-019-00757-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm153"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050310"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.168"},{"key":"e_1_2_12_14_1","volume-title":"Listening with the Whole Body: Clinical Concepts and Treatment Guidelines for Therapeutic Listening","author":"Frick S. 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