{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:37:48Z","timestamp":1791049068075,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["24077"],"award-info":[{"award-number":["24077"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fatigue and muscle weakness, often leading to significant impairments in quality of life (QOL). This single\u2010center cross\u2010sectional study investigated factors influencing QOL among MG patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010two participants diagnosed with MG were assessed using the MG Foundation of America (MGFA) classification and the MG composite (MGC) scale for disease severity. Patients completed validated questionnaires, including the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), MG Activities of Daily Living (MG\u2010ADL), and the MG Quality of Life 15\u2010item scale (MG\u2010QOL). Family stress levels were self\u2010reported and categorized as \u201cRarely\/Never,\u201d \u201cSometimes,\u201d \u201cOften,\u201d or \u201cAlways.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis revealed no significant differences in QOL scores based on sex, disease type, presenting symptoms, thymectomy status, or BMI. Employed or freelance patients exhibited significantly lower QOL and higher fatigue compared to retired or housewife groups. Higher family stress correlated with increased fatigue, worse MGC scores, and poorer QOL. Regression analysis identified the MG\u2010ADL and FSS scores as the strongest predictors of QOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>QOL in MG is influenced by complex interactions among functional, social, and occupational factors. These findings emphasize the need for tailored interventions to address fatigue and support occupational and familial well\u2010being in MG patients. Further research with larger cohorts is warranted to refine these insights and guide clinical strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70680","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T05:04:04Z","timestamp":1755839044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Influencing Quality of Life in Myasthenia Gravis Patients: Results From a Cross\u2010Sectional Study in South of Iran"],"prefix":"10.1002","volume":"15","author":[{"given":"Fatemeh","family":"Khodakarami","sequence":"first","affiliation":[{"name":"Clinical Neurology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arashk","family":"Mallahzadeh","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Fararouei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, HIV\/AIDS Research Center, School of Health Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Rahimi","family":"Jaberi","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-2232","authenticated-orcid":false,"given":"Maryam","family":"Owjfard","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-022-01919-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26719"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1972.11713319"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112235"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"35","article-title":"Validation of Myasthenia Gravis Activity of Daily Living Questionnaire: Persian Version","volume":"21","author":"Faghani S.","year":"2022","journal-title":"Current Journal of Neurology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/935429"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00032.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120268"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506310"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26694"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/85520"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.538"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/874680"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206754"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.364067"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.181542"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.933-a"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25002"},{"issue":"4","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/mus.1034","article-title":"Quality of Life and Well\u2010Being of Patients With Myasthenia Gravis","volume":"24","author":"Paul R. 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