{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:32:32Z","timestamp":1774881152633,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A strong association exists between anorexia nervosa (AN) and symptoms of depression, anxiety, and obsessive\u2010compulsive disorder (OCD). The levels of these psychiatric symptoms observed in AN may be influenced by different biological factors related to poor nutritional status and changes in thyroid hormone levels. Yet, few studies have investigated this relationship. The objective of this study is to examine the association between depression, anxiety, and obsessive\u2010compulsive (OC) symptoms and circulating thyroid hormones in a sample of undernourished patients with AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred and two patients with AN (DSM\u2010IV TR) were included in the study and were assessed upon admission for duration of illness, psychiatric treatments, sociodemographic data, and different psychopathological symptoms [depression (BDI), anxiety (HAD scale), obsessive\u2010compulsive (MOCI), social phobia (LSAS fear sub\u2010scale), and Eating Attitudes Test\u201026 (EAT\u201026)] using psychometric scales. Nutritional status was assessed with body mass index (BMI) and body composition using bioelectrical impedance. Upon patient admission, free\u2010T3 (fT3), free\u2010T4 (fT4), and TSH thyroid hormone plasma levels were collected, as well as albumin and transthyretin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Taking into consideration confounding factors, particularly the duration of AN evolution, thyroid hormone (fT3 and\/or fT4) blood levels can partially explain the levels of depression and OCD symptoms of the doubt type and social phobia in undernourished AN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A high prevalence of these symptoms among malnourished individuals requires investigation to differentiate between symptoms directly related to the biological effects of malnutrition and those indicative of a comorbid condition such as depression or anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70685","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T07:28:34Z","timestamp":1752218914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosa"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-1798","authenticated-orcid":false,"given":"Lama","family":"Mattar","sequence":"first","affiliation":[{"name":"Nutrition Program, Department of Nutrition and Food Science, School of Arts and Sciences Lebanese American University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Delaunay","sequence":"additional","affiliation":[{"name":"Service Universitaire De Psychiatrie De L'enfant Et De L'adolescent Centre Hospitalier de Versailles  Versailles France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2362","authenticated-orcid":false,"given":"Sylvie","family":"Berthoz","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INCIA, CNRS, UMR 5287, F\u201033000 Bordeaux France  Bordeaux France"},{"name":"Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeva","family":"Duquesnoy","sequence":"additional","affiliation":[{"name":"Paris\u2010Saclay University, INRAE, AgroParisTech MICALIS Institute  Jouy\u2010en\u2010Josas France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Iceta","sequence":"additional","affiliation":[{"name":"Research Center of the Quebec Heart and Lung Institute  Qu\u00e9bec QC Canada"},{"name":"Department of Psychiatry and Neurosciences Laval University  Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Lalane","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EVHAN group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Hanachi","sequence":"additional","affiliation":[{"name":"Clinical Nutrition department, Paul Brousse University Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Villejuif France"},{"name":"Paris\u2010Saclay University, INRAE, AgroParisTech MICALIS institute  Jouy\u2010en\u2010Josas France"},{"name":"Paris\u2010Saclay University, Le Kremlin\u2010Bic\u00eatre  Gif\u2010sur\u2010Yvette France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Godart","sequence":"additional","affiliation":[{"name":"UFR Simone Veil, UVSQ  Montigny le Bretonneux France"},{"name":"Fondation Sant\u00e9 des Etudiants de France  Paris France"},{"name":"\u00c9quipe INSERM Psychiatrie du d\u00e9veloppement, Centre de Recherche En \u00e9pid\u00e9miologie et Sant\u00e9 Des Populations, UMR 1018 Paris\u2010Saclay Universit\u00e9, Universit\u00e9 Versailles\u2010Saint\u2010 Quentin\u2010En\u2010Yvelines  Montigny\u2010Le\u2010Bretonneux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000963"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000395074"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20369"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(94)90315-8"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"211","article-title":"\u00c9tude Psychometrique Du Questionnaire De D\u00e9pression De Beck Aupr\u00e8s d'un \u00c9chantillon d'\u00e9tudiants Universitaires Francophones","volume":"14","author":"Bourque P.","year":"1982","journal-title":"Canadian Journal of Behavioural Science"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.06.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2011.09.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-0963-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(85)90027-5"},{"key":"e_1_2_12_11_1","unstructured":"Chronic Illness and Mental Health: Recognizing and Treating Depression. 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