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Neurological function scores were assessed 24\u00a0h after reperfusion, and then brain samples were collected to explore the mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 4\u00a0h of MCAO reperfusion for 24\u00a0h, the infarct area reached its peak, while the neurological function score reached its bottom, and both indicators exhibited a trend toward stabilization. Additionally, a significant increase in the mortality rate was observed in the 5\u2010h group. Compared to the MCAO 2\u2010h group, the 5\u2010h group exhibited a significant increase in the number of dead neurons, more serious disruption of the blood\u2013brain barrier (BBB), and elevated expression levels of IL\u20106, IL1\u2010\u03b2, and TNF\u2010\u03b1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, our study indicates that MCAO 4\u00a0h is likely to be the therapeutic time window for thrombectomy in rat models of middle cerebral artery ischemia\u2010reperfusion. Reperfusion injury beyond the time window leads to more severe disruption of the BBB, a significant increase in inflammatory products, and may ultimately result in a significant decline in neural function scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70713","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:34:12Z","timestamp":1754372052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia\u2010Reperfusion"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3597-7828","authenticated-orcid":false,"given":"Yuting","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Institute of Neurology, Jiangxi Academy 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