{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:57Z","timestamp":1772118057731,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011629"],"award-info":[{"award-number":["2024J011629"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013095","name":"Science and Technology Project of Longyan City","doi-asserted-by":"publisher","award":["2023LYF17043"],"award-info":[{"award-number":["2023LYF17043"]}],"id":[{"id":"10.13039\/501100013095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between inflammatory bowel disease (IBD) and Bell's palsy remains unsubstantiated. This study aims to investigate the causal relationship between IBD and Bell's palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the two\u2010sample Mendelian randomization (MR) method to explore the relationship between IBD and Bell's palsy. We applied Bell's palsy summary statistics from GWAS statistics for 91 inflammatory proteins and FinnGen R10 and IBD summary statistics from the International Inflammatory Bowel Disease Genetics Consortium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two\u2010sample MR study indicates a significant positive association between IBD and Bell's palsy (OR: 1.13, 95% CI [1.03\u20131.23],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0065) and between Crohn's disease and Bell's palsy (OR: 1.10, 95% CI [1.02\u20131.18],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0088). After applying Bonferroni correction, IBD remained significantly correlated with Bell's palsy. Subsequently, the causal relationship between circulating inflammatory proteins in Bell's palsy and inflammatory bowel disease samples was reevaluated. The results of the MR study on inflammatory proteins in these two diseases suggest that the C\u2010X\u2010C Motif Chemokine Ligand 5 (CXCL5) is a potential protective factor and interleukin_17C (IL_17C) is a risk factor for these two diseases. Conversely, Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) is a protective factor for Bell's palsy and a risk factor for inflammatory bowel disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings indicate that IBD may be a risk factor for Bell's palsy at the genetic level. CXCL5, IL_17C, and SLAMF1 are possible co\u2010acting pathways between Bell's palsy and inflammatory bowel disease. These findings may provide new targets for the treatment of both diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70715","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:44:08Z","timestamp":1754372648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Daofeng","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Neurology Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-7779","authenticated-orcid":false,"given":"Wenbao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqian","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinjuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion Xingwen County Hospital of Traditional Chinese Medicine  Yibin Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binfu","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion Longyan First Hospital Affiliated to Fujian Medical University  Longyan Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4189"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-325668"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2015.15456"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2023.102488"},{"issue":"4","key":"e_1_2_12_6_1","article-title":"Mendelian Randomization","volume":"12","author":"Birney E.","year":"2022","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238457"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00757-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.013"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.01.018"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309563"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117426"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.124"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.09.019"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.10.015"},{"issue":"41","key":"e_1_2_12_17_1","first-page":"692","article-title":"The Diagnosis and Treatment of Idiopathic Facial Paresis (Bell's Palsy)","volume":"116","author":"Heckmann J. 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