{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:26Z","timestamp":1772118146810,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the neural correlates of masking level differences (MLD) by examining their relationship with auditory brainstem responses (ABR) in normal\u2010hearing adults, to better elucidate the underlying brainstem mechanisms involved in MLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 37 normal\u2010hearing adults aged 18\u201330\u00a0years participated. Auditory evaluations included pure\u2010tone audiometry, tympanometry, MLD testing at 500\u00a0Hz under S\u2080N\u2080 and S\u03c0N\u2080 conditions, and click\u2010evoked ABR recordings. Correlations between ABR wave latencies (Waves I, III, and V) and interpeak intervals (I\u2013III, III\u2013V, and I\u2013V) with MLD scores were analyzed using Spearman's correlation. Multiple linear regression analyses were conducted in two separate models to evaluate the predictive contribution of ABR components to MLD performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean MLD was 13.24\u00a0\u00b1\u00a02.18\u00a0dB, exceeding the clinical threshold for normal performance. No significant gender differences were observed in ABR or MLD measures. A moderate positive correlation was found between ABR Wave V latency and MLD scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In regression analyses, Wave V latency was the only significant predictor of MLD scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), explaining 28% of the variance. Other ABR components were not significant contributors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results demonstrate that MLD performance is associated with ABR Wave V latency, suggesting that midbrain structures such as the inferior colliculus play a crucial role in binaural auditory processing. These findings support the utility of MLD as a behavioral index of brainstem integrity and its potential role in the evaluation of auditory dysfunction. While further research is needed to confirm these associations in clinical populations, MLD testing may offer valuable diagnostic insights into auditory brainstem dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70725","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:32:49Z","timestamp":1754371969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural Correlates of Masking Level Differences: Evidence From Auditory Brainstem Responses"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-2974","authenticated-orcid":false,"given":"Aysenur","family":"Aykul Yagcioglu","sequence":"first","affiliation":[{"name":"Department of Audiology KTO Karatay University  Konya Turkey"},{"name":"Institute of Health Sciences, Doctorate Program of Audiology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8912-3967","authenticated-orcid":false,"given":"Aysegul","family":"Esdogan","sequence":"additional","affiliation":[{"name":"Department of Audiology KTO Karatay University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7058-7519","authenticated-orcid":false,"given":"Aysun","family":"Parlak Kocabay","sequence":"additional","affiliation":[{"name":"Department of Audiology Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"ASHA.2025. \u201cCentral Auditory Processing Disorder.\u201d Accessed February 24.http:\/\/www.asha.org\/Practice\u2010Portal\/Clinical\u2010Topics\/Central\u2010Auditory\u2010Processing\u2010Disorder."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101722158"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HJ.0000425772.41884.1d"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1044\/2017_JSLHR\u2010H\u201016\u20100251"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/b-006-161125"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00206097509071749"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3601.210"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1982.tb50809.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/01050398709042149"},{"key":"e_1_2_9_11_1","volume-title":"Auditory Brainstem Evoked Potentials: Clinical and Research Applications","author":"Krishnan 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