{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:18Z","timestamp":1772118018992,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA030010"],"award-info":[{"award-number":["R01AA030010"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U10AA008401"],"award-info":[{"award-number":["U10AA008401"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trauma exposure during adolescence can lead to impaired executive function and altered neural development in related cognitive control networks. Studies have shown that adolescents with a family history of alcohol use disorders have a disproportionately high rate of trauma exposure, as well as impaired response inhibition, making them particularly vulnerable to cognitive impairment and poor mental health outcomes in adulthood. While studies have suggested that this may be due partly to genetic influences, no study to our knowledge has investigated the influences of trauma exposure and polygenic scores (PGS) for cognitive function on later cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study used data from trauma\u2010exposed individuals in the Collaborative Study on the Genetics of Alcoholism prospective cohort (\n                      <jats:italic>N<\/jats:italic>\n                      = 912), comprising offspring from alcohol\u2010dependent high\u2010risk and comparison families, to investigate main and interaction effects of PGS for cognitive function (fluid intelligence score, UK Biobank study) and trauma exposure (nonsexual assaultive, nonassaultive, sexual assaultive) on performance measures and frontal theta event\u2010related oscillations (EROs) during a continuous performance test (CPT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant interaction between fluid intelligence PGS and nonsexual assaultive trauma was observed for CPT ERO power (\n                      <jats:italic>B<\/jats:italic>\n                      = 0.094,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01), such that individuals with a lower PGS who experienced a nonsexual assaultive traumatic exposure had lower frontal theta ERO power during the cued no\u2010go condition of the CPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that a polygenic predisposition for higher fluid intelligence may be associated with differences in neural response inhibition depending on trauma type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70729","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:35:38Z","timestamp":1754372138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frontal Theta Event\u2010Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score"],"prefix":"10.1002","volume":"15","author":[{"given":"Stacey","family":"Saenz de Viteri","sequence":"first","affiliation":[{"name":"Department of Psychiatry State University of New York Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry State University 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