{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:06Z","timestamp":1772118066416,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the alterations in structural and functional connectivity networks (SCN and FCN) in children with hypothalamic syndrome (HS) following craniopharyngioma resection and to explore the relationship between these network changes and clinical manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed graph theory analysis on SCN and FCN derived from 36 patients with HS and 36 age\u2010 and sex\u2010matched healthy controls (HC), with an age range of 6 to 13 years. We evaluated characteristics, nodal properties, and the coupling between SCN and FCN across 90 brain nodes. Partial correlation analyses examined relationships between graph theory properties and clinical scales, including the Wechsler Intelligence Scale for Children (WISC), the Wechsler Memory Scale (WMS), and the Attention Deficit Hyperactivity Disorder (ADHD) scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SCN in the HS group exhibited abnormal global properties, including increased characteristic path length (Lp), decreased global efficiency (Eg), and local efficiency (ELOC), alongside notable reductions in nodal properties, such as degree centrality (Dc) and nodal efficiency (Ne) across multiple nodes. The FCN in the HS group also displayed abnormal global attributes, with elevated Lp and reduced Eg, alongside decreased Dc at the median cingulate and paracingulate gyri (DCG.L) node. However, no statistically significant differences were found in structural\u2010functional connectivity (SC\u2010FC) coupling between groups. Correlation analysis revealed significant links between WISC, WMS, and ADHD scales and various graph\u2010theoretic properties in the HS group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with HS following craniopharyngioma resection, alterations in SCN and FCN characteristics have been observed. These neural changes are associated with cognitive developmental impairments related to HS, providing neuroimaging evidence elucidating the mechanisms underlying cognitive deficits in HS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70730","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:58:23Z","timestamp":1756310303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alterations of Brain Structural and Functional Connectivity Networks and Its Correlations With Cognitive Function in Patients With Hypothalamic Syndrome Following Craniopharyngioma Resection"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7660-4209","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanyong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00276"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem\u20102015\u20100008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25848"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010014\u20109249\u20106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105699"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31821a872d"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.2.FOCUS09304"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010804281\u20106.00001\u2010X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(23)00162\u20106"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811168106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031054"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","unstructured":"Huang Z. 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