{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:12:28Z","timestamp":1777770748256,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guided internet\u2010based cognitive behavioral therapy (ICBT) provides an accessible alternative treatment for anorexia nervosa (AN), showing initial feasibility and effectiveness in the short term. However, limited research has explored its long\u2010term outcomes in outpatient settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the long\u2010term outcomes and cost\u2010effectiveness of guided ICBT in women with AN who were receiving outpatient treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study involved a 3\u2010year follow\u2010up of 11 adult women with AN who received guided ICBT in a previous trial. The Eating Disorder Examination Questionnaire (EDE\u2010Q) and body mass index (BMI) were used as outcomes to assess the severity of AN. A repeated\u2010measures ANOVA was conducted to assess differences in mean outcomes at baseline, post\u2010intervention, and two follow\u2010up time points. The incremental cost\u2010effectiveness ratio was calculated to estimate the cost\u2010effectiveness of this intervention, using quality\u2010adjusted life years (QALYs), derived from the EuroQol 5 Dimension 5\u2010Level (EQ\u20105D\u20105L), and costs from publicly available data from the Japanese healthcare system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From baseline, EDE\u2010Q global scores significantly decreased at the 1\u2010year (\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.72) and 3\u2010year follow\u2010ups (\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.65), while BMI significantly increased at the 1\u2010year (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.66) and 3\u2010year follow\u2010ups (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.98). The estimated incremental cost\u2010effectiveness ratio was notably low, at approximately JPY 111,000 (US$725) per year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These preliminary results suggest that guided ICBT may be effective in the long term for outpatients with AN. Since the threshold has been JPY 5 million in Japan, the current estimated incremental cost\u2010effectiveness ratio suggests that providing guided ICBT to outpatients with AN is likely to be cost\u2010effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70731","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:45:06Z","timestamp":1757396706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes of Guided Internet\u2010Based Cognitive Behavioral Therapy for Anorexia Nervosa: 3\u2010Year Follow\u2010Up"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7847-6381","authenticated-orcid":false,"given":"Sayo","family":"Hamatani","sequence":"first","affiliation":[{"name":"Research Center for Child Mental Development University of Fukui  Fukui Japan"},{"name":"Division of Developmental Higher Brain Functions United Graduate School of Child Development University of Fukui  Fukui Japan"},{"name":"Department of Child and Adolescent Psychological Medicine University of Fukui Hospital  Fukui Japan"},{"name":"Research Center for Child Mental Development Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology, Kagoshima University Hospital, Research and Education Assembly Medical and Dental Sciences Area Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumpei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Aoba Municipal Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development University of Fukui  Fukui Japan"},{"name":"Division of Developmental Higher Brain Functions United Graduate School of Child Development University of Fukui  Fukui Japan"},{"name":"Department of Child and Adolescent Psychological Medicine University of Fukui Hospital  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2009.01.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1201\/b13645"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20610"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160\u2010009\u20109130\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010018\u20100642\u20105"},{"key":"e_1_2_10_9_1","volume-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond M. 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