{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:16:01Z","timestamp":1776435361265,"version":"3.51.2"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23 MH127389"],"award-info":[{"award-number":["K23 MH127389"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH113533"],"award-info":[{"award-number":["R01 MH113533"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH124705"],"award-info":[{"award-number":["R01 MH124705"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Excitatory\/inhibitory (E\/I) imbalance is a proposed neural disruption in schizophrenia supported by magnetic resonance spectroscopic imaging (MRSI) evidence of altered gamma\u2010aminobutyric acid (GABA) and glutamate (Glu) levels. However, there exists a paucity of data linking these abnormalities to impaired in vivo brain function putatively reflecting E\/I imbalance. Here, associations between GABA\/Glu and the evoked early auditory gamma\u2010band response (EAGBR) were examined in first\u2010episode schizophrenia (FESz).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve FESz underwent resting\u2010state 7T\u2010MRSI and magnetoencephalography (MEG) recorded during an auditory oddball task. MRSI spectra and source\u2010localized MEG data were extracted from overlapping regions of left (LH) and right (RH) superior temporal sulcus. Associations between evoked EAGBR power and GABA\/Glu, GABA\/Cre, and Glu\/Cre ratios were assessed. The Brief Psychiatric Rating Scale (BPRS) and Global Functioning: Role\/Social (GF: Role\/Social) scales were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GABA\/Glu ratios were inversely correlated with EAGBR power (LH:\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = \u22120.87; RH:\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = \u22120.85). LH GABA\/Glu ratios were also inversely correlated with BPRS scores (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = \u22120.64) and positively correlated with GF: Social (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.64) scores while RH EAGBR power was positively correlated with BPRS scores (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.70). Stepwise linear regressions suggest these relationships were driven primarily by GABA concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Associations in FESz between GABA\/Glu ratios, clinical ratings, and EAGBR power suggests this evoked gamma\u2010band response reflects cortical hyperexcitability within the auditory system that is closely tied to disease debility at this early illness stage. These data highlight the potential of merging high\u2010precision, in vivo neuro\u2010chemical assays via 7\u2010Tesla MRSI and physiological measures from MEG to validate established cellular models of disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70735","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:31:19Z","timestamp":1754371879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Synergistic Examination of Excitatory\u2010Inhibitory Balance in First\u2010Episode Schizophrenia Merging 7\u2010Tesla Magnetic Resonance Spectroscopic Imaging and Magnetoencephalography"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-7643","authenticated-orcid":false,"given":"Alfredo L.","family":"Sklar","sequence":"first","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Blazer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Snover","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran","family":"L\u00f3pez\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Washington University  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-5105","authenticated-orcid":false,"given":"Brian A.","family":"Coffman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoby H.","family":"Hetherington","sequence":"additional","affiliation":[{"name":"Resonance Research Incorporated  Billerica Massachusetts USA"},{"name":"Department of Radiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan\u2010Hong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Radiology Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean F.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak K.","family":"Sarpal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pittsburgh University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania 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