{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:57:26Z","timestamp":1787756246846,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>Evidence has already shown that sarcopenia is linked to an elevated risk of cardiovascular disease (CVD). However, the association between stroke and sarcopenia risk remains underexplored in stroke and non\u2010stroke populations. This study investigated the stroke\u2013sarcopenia relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis using data from Wave 3 (2015\u20132016) of the China Health and Retirement Longitudinal Study (CHARLS) and Wave 14 (2018\u20132019) of the Health and Retirement Study (HRS), focusing on \u2265\u00a050 years adults. Missing data were imputed using the Python miceforest package with a random forest algorithm. All types of stroke were identified via self\u2010reported records where individuals had received a confirmed diagnosis from a physician. Sarcopenia status was evaluated using muscle strength (evaluated with grip strength in CHARLS and HRS), muscle mass (evaluated with appendicular skeletal muscle), and physical performance (evaluated with gait speed, the five\u2010repetition chair test, and the short physical performance battery). Logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) for the primary analysis, with generalized estimating equation (GEE) models employed in sensitivity analyses to ensure result robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study comprised 16,859 participants from CHARLS (51% female, mean age 62.9\u00a0years) and 16,692 from HRS (41% female, mean age 67.6\u00a0years). In CHARLS, stroke was associated with significantly increased risks of possible sarcopenia (OR: 2.07, 95% CI: 1.49\u20132.99), sarcopenia (OR: 1.93, 95% CI: 1.23\u20133.06), and severe sarcopenia (OR: 3.42, 95% CI: 2.22\u20135.34). In HRS, stroke was linked to elevated risks of possible sarcopenia (OR: 3.11, 95% CI: 2.75\u20133.52) and severe sarcopenia (OR: 2.20, 95% CI: 1.24\u20133.65). Self\u2010care ability, nutritional status, and inflammatory factors were identified as key mediators, with findings remaining consistent across subgroups and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stroke was associated with increased risk for sarcopenia and its severe forms in adults aged \u2265\u00a050 years. We recommend sarcopenia risk evaluation in poststroke patients with accessible tools, also emphasizing that functional rehabilitation, nutritional optimization, and inflammation control hold promise to alleviate sarcopenia risk and enhance long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70763","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:03:41Z","timestamp":1754985821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insights Into the Association Between Stroke and Sarcopenia Risk in Adults Aged \u2265 50 Years: Cross\u2010Sectional Evidence From Two Large Population Longitudinal Cohorts"],"prefix":"10.1002","volume":"15","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Center For Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-5224","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center For Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Center For Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Center For Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1239-8086","authenticated-orcid":false,"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Center For Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(08)00019-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000677"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0062-9"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.08.027"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf115"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.008"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-025-04136-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008574"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000570"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020786"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzx038"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101264"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1191\/026921501669958740"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00642-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201701-059SR"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13081"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.780080"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010113"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03016.x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.16591"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101708"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9577-y"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.111028"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051293"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13808"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000464"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311408920"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106220"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac220"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.12.007"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.031"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.07.013"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01126-1"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.12.002"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006258"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105092"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30059-3"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1455"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025250"},{"issue":"4","key":"e_1_2_13_52_1","first-page":"551","article-title":"Anthropometric Equation for Estimation of Appendicular Skeletal Muscle Mass in Chinese Adults","volume":"20","author":"Wen X.","year":"2011","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.019"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.04182"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-023-2001-2"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007716"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:14:36Z","timestamp":1758867276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/brb3.70763"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70763","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70763\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70763\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70763\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70763\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70763"}}