{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:55:43Z","timestamp":1786636543339,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to examine the levels of serum Nrf2 in patients with severe traumatic brain injury (STBI) and assess its predictive value for 28\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study prospectively observed 252 patients with STBI who were admitted to our ICU between January 2018 and April 2024. Serum samples were collected within 24\u00a0h of admission, and levels of nuclear factor erythroid 2\u2010related factor 2 (Nrf2) and inflammatory cytokines were measured using ELISA. Additionally, the mortality rate within 28 days after admission to the ICU was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this prospective observational study, based on the 28\u2010day mortality after admission to the ICU, the patients were categorized into two groups based on their outcomes: the survival group (\n                      <jats:italic>n<\/jats:italic>\n                      = 184) and the deceased group (\n                      <jats:italic>n<\/jats:italic>\n                      = 68). Compared to the survival group, the deceased group exhibited lower serum Nrf2 levels and higher IL\u20106 and IL\u201017 levels. Spearman correlation analysis revealed a negative correlation between serum Nrf2 levels and serum IL\u20106, IL\u20101\u03b2, and IL\u201017 levels, while a positive correlation was observed between serum Nrf2 levels and GCS scores. The ROC curve indicated that serum Nrf2 could be used to predict the 28\u2010day mortality in patients with STBI. Finally, multivariate logistic regression analysis showed that serum Nrf2, IL\u20106, and IL\u201017 levels were independently associated with 28\u2010day mortality in STBI patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, we observed significantly lower serum Nrf2 levels in deceased STBI patients compared to the survival group. Additionally, Nrf2 could be used as a potential marker to predict 28\u2010day mortality in STBI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70786","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:14:17Z","timestamp":1763792057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Nrf2 Levels in Severe Traumatic Brain Injury Patients and Its Significance in Predicting 28\u2010Day Mortality"],"prefix":"10.1002","volume":"15","author":[{"given":"Gongjian","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Nanjing Tongren Hospital, School of Medicine, Southeast University  Nanjing Jiangsu 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