{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:09:47Z","timestamp":1778742587708,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016101","name":"Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This observational cohort study investigates how infection health factors influence COVID\u201019 severity and cognitive outcomes. We collected preinfection data from hospitalized COVID\u201019 patients, including demographic information and baseline health conditions prior to diagnosis, and examined their associations with hospitalization duration and cognitive function assessed after infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from Hui Ya Hospital, The First Affiliated Hospital, Sun Yat\u2010sen University, China. The study included confirmed COVID\u201019 patients requiring hospitalization. Among the 147 collected cases, two were excluded due to missing data, leaving a final sample of 145 patients. The Montreal Cognitive Assessment (MoCA), which evaluates global cognitive function with a total score of 0\u201330, was used to assess cognitive function, while hospitalization duration and routine clinical examinations were analyzed as indicators of disease severity. Additionally, the SF\u201012v2 score reflecting Health\u2010Related Quality of Life was used to evaluate patients' overall health status. Statistical analyses were conducted to identify preinfection factors associated with COVID\u201019 outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preinfection baseline health status was significantly correlated with both hospitalization duration (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001, 95% CI [\u22120.47, \u22120.16]) and MoCA scores (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001, 95% CI [0.15, 0.46]). Patients with better preinfection health conditions experienced shorter hospital stays and demonstrated better cognitive function postinfection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that preinfection baseline health conditions play a crucial role in determining both the severity of COVID\u201019 and postinfection cognitive function. Specifically, impairments were more pronounced in the visuospatial, naming, attention, calculation, language, and memory domains. Additionally, our results suggest a potential link between COVID\u201019 outcomes and patients\u2019 preexisting underlying diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70793","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:20:07Z","timestamp":1759904407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Preinfection Health Status on COVID\u201019 Severity and Cognitive Function"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2927-9987","authenticated-orcid":false,"given":"Kang","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-3534","authenticated-orcid":false,"given":"Wenbiao","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-371X","authenticated-orcid":false,"given":"Wenli","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology  Guangzhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanling","family":"Wu","sequence":"additional","affiliation":[{"name":"Nursing Department Hui Ya Hospital of The First Affiliated Hospital, Sun Yat\u2010Sen University  Huizhou Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.857573"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02964-2020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-022-00515-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-1238OE"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"665","article-title":"Infectability of Human Brain Sphere Neurons Suggests Neurotropism of SARS\u2010CoV\u20102","volume":"37","author":"Bullen C. 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