{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:12:23Z","timestamp":1777770743534,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Meningiomas, the second most common intracranial tumors, account for over one\u2010third of primary central nervous system tumors. Recent studies suggest a link between trace elements, nutrients, and tumor development. This study used Mendelian randomization (MR) to investigate causal links between trace elements, nutrients, and meningioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data for trace elements and nutrients were derived from the published IEU OpenGWAS database. The genome\u2010wide association study data for meningiomas were sourced from the Finnish database. Two\u2010sample MR approach was leveraged to examine the causal link of seven trace elements and eight nutrients with meningioma. Inverse\u2010variance weighted (IVW), MR\u2010Egger test, and weighted median methods were applied to infer causal links. Sensitivity analyses were performed to examine the robustness of the results. Reverse MR (RMR) analysis was further carried out with meningiomas as the exposure factor and trace elements and nutrients as the outcome. A multivariable MR (MVMR) method was adopted to appraise the combined effects of several exposure factors on meningioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two\u2010sample MR analysis revealed that Zn (OR = 1.484, 95% CI: 1.222\u20131.803,\n                      <jats:italic>p<\/jats:italic>\n                      = 6.90E\u201005), as an exposure factor, may increase the risk of meningioma. The RMR analysis indicated no evident causal connection. According to the MVMR analysis, Zn was an independent risk factor for meningiomas (OR = 1.391, 95% CI: 0.042\u20130.617,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Zn is an independent risk factor for meningioma, which is significant for developing prevention and management strategies for meningioma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70852","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:31:46Z","timestamp":1756881106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causal Link of Seven Trace Elements and Eight Nutrients With Meningioma: A Bidirectional Two\u2010Sample Mendelian Randomization Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4393-0624","authenticated-orcid":false,"given":"Yihong","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Third People's Hospital of Datong  Datong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieqiong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third People's Hospital of Datong  Datong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third People's Hospital of Datong  Datong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajiang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third People's Hospital of Datong  Datong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000382"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0047-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2017.11.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7221"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1346"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7735"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21998"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1430606"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01679-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2199-9_13"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30098-w"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-17"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12127"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt239"},{"key":"e_1_2_9_20_1","unstructured":"FinnGen: An Expedition Into Genomics and Medicine. n.d. 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