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We aimed to explore the associations between various demographic characteristics, lifestyle factors, and biological factors that have the potential to contribute to magnetic susceptibility and investigate the comprehensive impact of these multiple factors on basal ganglia susceptibility values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 25,980 participants from the UK Biobank. Linear regression analysis was employed to assess the relationship between basal ganglia susceptibility values and demographic characteristics (age, sex, ethnicity), lifestyle factors (tea consumption, coffee intake, smoking status, alcohol consumption, physical activity, insomnia status), and biological factors (C\u2010reactive protein, blood cell counts, anthropometric measures, blood pressure parameters).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multiple factors demonstrated significant associations with basal ganglia iron deposition. Among biological factors, C\u2010reactive protein showed significant positive correlations with susceptibility values in the caudate nucleus (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.028,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), globus pallidus (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.046,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and substantia nigra (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.031,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Waist circumference, another biological measure, had substantial positive effects on most basal ganglia regions (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.115 in caudate,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.122 in putamen,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.058 in globus pallidus). Among lifestyle factors, current smoking status was significantly associated with increased susceptibility values across all four basal ganglia nuclei (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.053\u20130.061, all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Tea consumption demonstrated dose\u2010dependent protective effects, with daily consumption of \u2265\u00a04 cups showing significant negative associations with all basal ganglia regions (\u22120.032 to \u22120.093 standard deviations). Age demonstrated significant positive associations with most basal ganglia regions. Gender differences were observed in tea consumption effects, with females showing stronger protective benefits (5.59\u00a0vs. 1.50 years of equivalent \u201crejuvenation\u201d effect for 0\u20133 cups daily).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provide evidence for multiple demographic, lifestyle, and biological factors influencing brain iron deposition in healthy middle\u2010aged and elderly individuals. Systemic inflammation, smoking, and increased adiposity were associated with greater iron deposition, while tea consumption showed protective effects. These findings highlight potential targets for interventions aimed at maintaining brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics approval and consent to participate<\/jats:title>\n                    <jats:p>The UK Biobank protocol was approved by the NHS North West Multicentre Research Ethics Committee (21\/NW\/0157). All participants provided informed consent at recruitment, allowing for follow\u2010up using data linkage to health records.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70862","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:15:09Z","timestamp":1757571309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Demographic, Lifestyle, and Biological Factors Associated With Brain Iron Deposition in the Basal Ganglia: A Comprehensive Analysis of 25,980 UK Biobank Participants"],"prefix":"10.1002","volume":"15","author":[{"given":"Pengcheng","family":"Liang","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong Province 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