{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:13:31Z","timestamp":1777770811403,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A high prevalence of COVID\u201019\u2010related anxiety was observed among the general population during the COVID\u201019 pandemic. Patients with myasthenia gravis (MG) might be at higher risk for COVID\u201019\u2010related anxiety due to immunosuppressive therapy in the majority of cases and risk of myasthenic exacerbation in case of an infection. This prospective longitudinal study assessed COVID\u201019\u2010related anxiety in MG patients over 2 years of the pandemic and its association with MG\u2010specific factors (e.g., disease severity, immunosuppressive medication) and with vaccination status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A three\u2010wave longitudinal online survey was conducted from May 2020 to February 2022, including a total of 648 adult MG patients. Descriptive, univariate, and multivariate analyses were performed to assess COVID\u201019\u2010related and MG\u2010related anxiety, associated MG\u2010specific factors, and association with vaccination status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>COVID\u201019\u2010related anxiety was frequent, with the most pronounced fear being risk for one's own health (overall 83.9%). Anxiety was influenced by MG diagnosis (overall 75.1%), especially by fear of exacerbation of myasthenic symptoms and greater risk of infection due to immunosuppressive therapy. Female sex and treatment with immunosuppressive medication, including rituximab, were associated with an increased concern for one's own health. Fear for one's own health was the only factor associated with vaccination status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COVID\u201019\u2010related anxiety was prevalent among MG patients. An ongoing psychological impact is likely and highlights the need for anxiety screening in clinical practice. Our findings emphasize the importance of addressing mental health challenges during future pandemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70878","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:30:14Z","timestamp":1758087014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anxiety in Myasthenia Gravis Patients Throughout the COVID\u201019 Pandemic\u2013Prevalence, Risk Factors, and Association With Vaccination Status"],"prefix":"10.1002","volume":"15","author":[{"given":"Janna","family":"Beckmann","sequence":"first","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Petzold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin Berlin Germany"},{"name":"Department of Psychology\u2013Medical School Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Betzler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Str\u00f6hle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin Berlin 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