{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:28:08Z","timestamp":1790954888038,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Magnetoencephalography (MEG) offers high temporal resolution and whole\u2010brain spatial coverage, making it a powerful tool to study brain networks. This systematic review examines the use of MEG to study Parkinson's disease (PD) brain network dysfunction, providing an update on scientific advances and identifying knowledge gaps that can be addressed using MEG as a research platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Five databases (Cochrane, Embase, PubMed, Scopus, and Web of Science) were systematically searched for MEG\u2010based PD publications from October 2018 (the date of the latest search in the previous systematic review) to June 2025. We used the\u00a0Joanna Briggs Institute (JBI) checklist to individually assess each paper for quality and relevancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>Fifty\u2010four publications were grouped into motor or cognitive domains. Motor resting\u2010state studies were further categorized into four groups: (1) Cortical Pathophysiology and its Modulation by Therapies, (2) Basal Ganglia\u2010Cortical (BGC) Network Pathophysiology and its Modulation by Therapies, (3) Temporal Dynamics, Aperiodicity, and Nonlinearity in PD, and (4) Clinical Utility of MEG. We highlight increases in cortical beta power in response to L\u2010DOPA and its correlation with motor symptom improvement, the broad cortical distribution of beta\u2010gamma phase\u2010amplitude coupling (PAC) in PD and its link to motor symptoms, corticocortical connectivity modulation in response to different treatments, and the integration of MEG with local field potentials to study cortico\u2010subcortical abnormalities. Temporal dynamics, such as cortical beta bursts and reduced functional repertoire, are explored, as well as aperiodic components and nonlinearities in the power spectrum in PD. Clinically, MEG shows promise in optimizing DBS, predicting L\u2010DOPA response, and uncovering movement\u2010related and cognitive pathophysiology in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Key PD knowledge gaps that can be addressed using MEG are identified, including the need to characterize network temporal dynamics and signal interrelation in PD, the causal pathological mechanisms of the disease, and the response to different treatment modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70889","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:27:28Z","timestamp":1758522448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic 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