{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:33:19Z","timestamp":1787506399003,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L232130"],"award-info":[{"award-number":["L232130"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62271061"],"award-info":[{"award-number":["62271061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["83161120402"],"award-info":[{"award-number":["83161120402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS083503"],"award-info":[{"award-number":["R01 NS083503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the potential value of serum inflammatory markers combined with carotid plaque characteristics for predicting subsequent recurrent ischemic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with cerebral infarction localized to the internal carotid artery territory were recruited. Carotid MRI examinations were performed, and the plaque characteristics were evaluated at baseline. Serum samples were obtained, and clinical characteristics were documented at baseline. All participants received clinical follow\u2010up 1\u00a0year after discharge. Recurrent ipsilateral ischemic stroke was considered the clinical endpoint. Logistic regression analyses were employed to assess the correlations between serum inflammatory biomarkers, plaque characteristics, and the endpoint. The diagnostic performances were evaluated using receiver operating characteristic curves. DeLong's test was used to compare the areas under the curve (AUCs) of the models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 89 patients (84.3% men; mean age, 56.57\u00a0\u00b1\u00a09.05\u00a0years) with recent anterior circulation (carotid territory) cerebral hemisphere ischemia were included. Sixteen patients presented with an endpoint within the 1\u2010year follow\u2010up. Multivariate logistic regression demonstrated that the normalized wall index, intraplaque hemorrhage, lipid\u2010rich necrotic core, and high\u2010sensitivity C\u2010reactive protein (Hs\u2010CRP) were associated with the endpoint. The model combining plaque characteristics and Hs\u2010CRP had the highest diagnostic performance with an AUC of 0.855.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum Hs\u2010CRP level and plaque characteristics may provide complementary information for predicting recurrent stroke. The combination of these two indicators may be a better potential predictor of the population at high risk of stroke recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70909","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:37:49Z","timestamp":1759905469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Carotid Plaque Characteristics Combined With Serum Inflammatory Biomarkers Predict Recurrent Ischemic Stroke"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2296-7366","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Neurology Beijing Daxing Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Tiantan Neuroimaging Center for Excellence China National Clinical Research Center for Neurological Diseases Beijing Neurosurgical Institute Beijing Tiantan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research Department of Biomedical Engineering Tsinghua University School of Medicine Beijing China"},{"name":"Department of Radiology and Imaging Sciences, Spencer Fox Eccles School of Medicine University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hatsukami","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-0566","authenticated-orcid":false,"given":"Xihai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research Department of Biomedical Engineering Tsinghua University School of Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Tiantan Neuroimaging Center for Excellence China National Clinical Research Center for Neurological Diseases Beijing Neurosurgical Institute Beijing Tiantan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-5147","authenticated-orcid":false,"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Capital Medical University Beijing China"},{"name":"Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Hospital. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2017.1281196"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010022\u201002758\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11136"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.30.9.1751"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30925\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095135\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.05.008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23918"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101651523"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033152"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.012901"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27038"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2965"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61728\u20100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019422"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104653"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4893"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003657"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.04.488"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010019\u20100388\u20102"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29522"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2019.08.028"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.09.005"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30035\u20103"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.04.003"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn\u20102020\u2010000369"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025250"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.16341"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090142"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005831"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010015\u20100143\u2010z"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.70909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:27:51Z","timestamp":1778740071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/brb3.70909"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70909","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70909"}}