{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:08:59Z","timestamp":1778742539734,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The brain network correlates of personality traits in major depressive disorder (MDD) have not yet been investigated. Furthermore, it is still unclear whether personality traits relate to the depressive episode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study assessed network properties, depression severity, and personality traits in patients with MDD (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) compared with age\u2010 and sex\u2010matched healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      = 22). We performed TCI questionnaire which assesses novelty seeking (NS, an urge to explore new experiences with heightened emotional responses), harm avoidance (HA, the tendency to hold back when faced with unpleasant situations), reward dependence (RD, a tendency to seek and value rewards rooted in social recognition), persistence (P, an individual's ability to remain focused and driven toward goals despite encountering challenges), self\u2010directness (SD, an expression of willpower that enables individuals to adapt their behavior to situational demands while remaining focused on their personal goals and values), cooperativeness (C, a behavioral trait reflecting a person's general approach to others; ranging from friendly and cooperative to hostile), and self\u2010transcendence (ST, lessening of self\u2010centeredness, allowing for expanded empathy) traits of participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MDD patients with distinctive character traits exhibited significant differences in terms of depression diagnosis and severity of Hamilton Depression Rating Scale scores compared to the controls. The MDD patients also exhibited reduced resting\u2010state network activity between the posterior default mode network, right putamen, and right frontal pole, while SD was significantly less frequently diagnosed in MDD patients. In evaluating the network correlates, differences in the SD traits were significantly associated with critical brain network alterations that were not evident in other traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first study to provide preliminary evidence of an abnormal connectome in the SD trait in MDD, thus providing convincing evidence for personalized antidepressant treatment strategies in MDD. A small sample size and our depression group being not drug\u2010naive were our limitation for this research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70921","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:43:46Z","timestamp":1761025426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Willpower in Major Depressive Disorder: An fMRI Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-6173","authenticated-orcid":false,"given":"Burak","family":"Yulug","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dila","family":"Sayman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-0351","authenticated-orcid":false,"given":"Seyda","family":"Cankaya","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behcet","family":"Ayy\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Anatomy PhD Program, Graduate School of Health Sciences Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevilay","family":"Ayy\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Anatomy PhD Program, Graduate School of Health Sciences Kocaeli University  Kocaeli Turkey"},{"name":"Department of Neuroradiology, School of Medicine Technical University of Munich  Munich Germany"},{"name":"TUM\u2010NIC Neuroimaging Center, School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ece Ozdemir","family":"Oktem","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aynur","family":"Akturk","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Ozsimsek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Alanya Alaaddin Keykubat University  Alanya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Behram","family":"Salar","sequence":"additional","affiliation":[{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN), Health Sciences and Technology Research Institute (SABITA) Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ozansoy","sequence":"additional","affiliation":[{"name":"Department of Physiology Bahcesehir University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfu","family":"Hanoglu","sequence":"additional","affiliation":[{"name":"Department of Neurology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Altay","sequence":"additional","affiliation":[{"name":"KTH Royal Institute of Science and Technology  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil Aziz","family":"Velioglu","sequence":"additional","affiliation":[{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN), Health Sciences and Technology Research Institute (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Center for Psychiatric Neuroscience Feinstein Institutes for Medical Research  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Mardinoglu","sequence":"additional","affiliation":[{"name":"KTH Royal Institute of Science and Technology  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20100327(01)00393\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S153273"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10120915"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2008.11.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(95)00041\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsad032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959\u20104388(94)90083\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195051377.001.0001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820240059008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.01.027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800213-1.00091-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2017.0156"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_9_16_1","first-page":"1","volume-title":"Encyclopedia of Personality and Individual Differences","author":"Garcia D.","year":"2017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.03.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0538050100"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.9.1436"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.2.252"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010006\u20100159\u20103"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/431314"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.09.017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2013.05.010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12172"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100574\u20102"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22174"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0030426"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23648"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0886260517724256"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.056"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20215"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(00)01036\u20102"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.5.461"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.01.029"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(20)30151\u20106"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191\u20108869(01)00121\u20100"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.03.150"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.160010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1515"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_406_18"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22739"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.03.005"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/pen.2017.2"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207594.2011.554553"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171200164X"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20108119(03)00171\u2010X"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2017.06.004"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.05.036"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.600533"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.70921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:25:35Z","timestamp":1778739935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/brb3.70921"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70921","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70921\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70921\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70921\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70921\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70921"}}