{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:08:54Z","timestamp":1778742534507,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cognitive impairment is frequently observed in patients with diabetes mellitus (DM), and this condition worsens in those with diabetic kidney disease (DKD). However, the precise neural mechanisms involved are still not fully understood. The present study aimed to investigate the topological organization of individual\u2010level gray matter (GM) structural networks in patients with DKD and its association with clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Structural magnetic resonance imaging data were collected from 50 DKD patients, 65 DM patients, and 70 healthy controls (HCs). Following data processing, individualized similarity\u2010based GM morphological networks were created. The topological properties of these networks were analyzed using graph theory analysis and compared among the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both patient groups showed lower local efficiency and clustering coefficient (\n                      <jats:italic>\n                        C\n                        <jats:sub>p<\/jats:sub>\n                      <\/jats:italic>\n                      ) than the HC group, with DKD patients showing a further reduction in\n                      <jats:italic>\n                        C\n                        <jats:sub>p<\/jats:sub>\n                      <\/jats:italic>\n                      compared to DM patients. Additionally, both patient groups showed lower nodal centralities mainly in the frontal regions (including right dorsolateral superior frontal gyrus and bilateral middle frontal gyrus) and left lingual gyrus, while DKD patients exhibited further reductions in these regions compared to DM patients. Nodal centralities of the right dorsolateral superior frontal gyrus and left middle frontal gyrus were associated with kidney function indicators and cognitive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study indicates a progressive disruption of the GM structural connectome in patients with DKD compared to those without kidney complications. This disruption may be the underlying neural substrate that leads to more severe cognitive impairment in DKD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70932","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:35:53Z","timestamp":1758976553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deteriorated Gray Matter Connectome in Diabetic Kidney Disease: A Graph Theory Analysis of Individual\u2010Level Gray Matter Morphological Networks"],"prefix":"10.1002","volume":"15","author":[{"given":"Fangliang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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