{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:59Z","timestamp":1787602979562,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trigeminal neuralgia (TN) patients are at risk for glymphatic dysfunction due to their prolonged headaches and sleep disturbances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to compare the glymphatic function changes in TN patients with healthy controls, to investigate whether there are differences in glymphatic function after decompression surgery, and to examine their relationship with clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data for this hybrid design study were obtained from the OpenNeuro dataset titled \u201cA large\u2010scale dataset of pre\u2010 and post\u2010surgical MRI data in patients with chronic trigeminal neuralgia.\u201d The DTI\u2010ALPS index values were calculated for 62 TN patients with normal brain MRIs and 35 age\u2010 and sex\u2010matched healthy controls, as well as for 53 TN patients who had both preoperative and postoperative diffusion tensor imaging. Statistical analyses involved nonparametric tests and Spearman correlation to assess differences between groups and relationships with clinical variables such as age, disease duration, and Sindou grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences in DTI\u2010ALPS indices between TN patients and controls. Additionally, preoperative and postoperative comparisons in the TN cohort revealed no significant changes in glymphatic function following surgery. Furthermore, no correlations were observed between DTI\u2010ALPS indices and clinical parameters, including patient age, disease duration, or the severity of neurovascular compression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this preliminary study suggest that glymphatic dysfunction is not a contributing factor in the pathogenesis of TN and that microvascular decompression surgery does not alter glymphatic clearance. These results indicate that the underlying mechanisms of TN may be independent of glymphatic impairment, despite the presence of sleep disturbances in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70938","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:35:31Z","timestamp":1769589331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["No Glymphatic Dysfunction in Trigeminal Neuralgia: A Preliminary Study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-6373","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Gen\u00e7","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Radiology Ondokuz May\u0131s University  Samsun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"Aslan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Radiology Ondokuz May\u0131s University  Samsun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-024-01368-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.62087\/hpr.2024.0014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101572"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00121"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806920901890"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1138769"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01544-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0528"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.07.027"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1581-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201300"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28977"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26054"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2631"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100930"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14320"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.12.013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9529-2"},{"issue":"4","key":"e_1_2_7_23_1","first-page":"1885","article-title":"Cross\u2010Vendor Test\u2010Retest Validation of Diffusion Tensor Image Analysis Along the Perivascular Space (DTI\u2010ALPS) for Evaluating Glymphatic System Function","volume":"15","author":"Liu X.","year":"2024","journal-title":"Aging and Disease"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2025.02.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001117"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.11.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-023-03270-2"},{"key":"e_1_2_7_28_1","unstructured":"Skare S. andR.Bammer.2010.Jacobian weighting of distortion corrected EPI data. 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