{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:37:06Z","timestamp":1790699826854,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Callous\u2010unemotional (CU) traits during adolescence, for example, shallow affect or lack of remorse, have been shown to be a risk marker for antisocial behavior. Only a few studies have investigated structural brain alterations underlying CU traits, and findings are inconclusive. The study examines CU symptomatology and gray matter volume (GMV) associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Structural brain MRI data were collected from a sample of 578 adolescents (60% male) with a mean age of 14.85 years (SD = 2.30; range = 10\u201319 years). CU traits were indexed via the Inventory for Callous Unemotional Traits (ICU). Region\u2010wise volumetric parameters were obtained following parcellation of the brain into 68 cortical and 14 subcortical regions per participant. A multiple linear regression was conducted using age, sex, IQ, intracranial volume, and handedness as covariates to assess the relationship between ICU scores and GMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our regression analysis showed significance (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.244,\n                      <jats:italic>F<\/jats:italic>\n                      [87,490] = 1.821,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Specifically, GMV of the left parahippocampal gyrus, left pars orbitalis, right medial orbitofrontal cortex, right superior temporal, and right putamen had significant negative regression loadings, indicating those with lower GMV in these regions had higher ICU scores. The right postcentral gyrus and right hippocampus had significant positive regression loadings, indicating those with higher GMV in these regions had higher ICU scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Utilizing a transdiagnostic sample of adolescents, our study found significant associations between CU traits and GMV. Understanding the neurobiological associations of CU traits could be crucial for early intervention and targeted treatments, particularly for those at risk of antisocial behavior.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70941","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:12:59Z","timestamp":1759216379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alterations in Region\u2010Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents"],"prefix":"10.1002","volume":"15","author":[{"given":"Johannah","family":"Bashford\u2010Largo","sequence":"first","affiliation":[{"name":"Child and Family Translational Research Center Boys Town National Research Hospital  Boys Town Nebraska USA"},{"name":"Center For Brain, Biology, and Behavior University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. James R.","family":"Blair","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina S.","family":"Blair","sequence":"additional","affiliation":[{"name":"Center For Neurobehavioral Research Boys Town National Research Hospital  Boys Town Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-3725","authenticated-orcid":false,"given":"Jaimie","family":"Elowsky","sequence":"additional","affiliation":[{"name":"Brain Development Laboratory Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dobbertin","sequence":"additional","affiliation":[{"name":"Inpatient Psychiatric Care Unit Boys Town National Research Hospital  Boys Town Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahria J.","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Clinical Health, Emotion, and Neuroscience (CHEN) Laboratory, Department of Neurological Sciences, College of Medicine University of Nebraska Medical Center (UNMC)  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Hatch","sequence":"additional","affiliation":[{"name":"Cognitive and Affective Psychophysiology (CAP) Lab, Department of Psychology Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Patrick","sequence":"additional","affiliation":[{"name":"Child and Family Translational Research Center Boys Town National Research Hospital  Boys Town Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-6036","authenticated-orcid":false,"given":"Sahil","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Cancer Systems Imaging, Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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