{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:09:03Z","timestamp":1778742543106,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Behavioral Inhibition System (BIS) and the Behavioral Approach System (BAS) are two core motivational systems linked to addictive behaviors. Understanding the biobehavioral mechanisms and correlates of Alcohol Use Disorder (AUD), including BIS\/BAS, could lead to improved strategies for prevention, diagnosis, and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using baseline data from five clinical studies, we conducted secondary analyses to explore the link between BIS\/BAS and alcohol\u2010related outcomes in people with AUD (\n                      <jats:italic>N<\/jats:italic>\n                      = 94). We hypothesized that lower BIS and higher BAS scores would be associated with more severe alcohol use, obsessive thoughts, and compulsive behaviors toward alcohol. In additional post\u2010hoc analyses, we also explored the mediating effects of anxiety and depression in this regard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher BIS scores were associated with higher severity of alcohol use and more obsessive\u2010compulsive drinking behaviors, as respectively measured by the Alcohol Use Disorder Identification Test (AUDIT) and the Obsessive\u2010Compulsive Drinking Scale (OCDS). Anxiety (Spielberger State\u2010Trait Anxiety Inventory) and depression (Montgomery\u2013Asberg Depression Rating Scale) significantly mediated the positive associations between BIS scores and AUDIT\/OCDS. No significant associations were found between BAS scores and alcohol\u2010related measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that, in this sample of middle\u2010aged people with AUD, a heightened BIS leads to more severe alcohol use, and this relationship is mediated by anxiety and depressive symptoms. Further prospective research in adults with AUD and varying levels of alcohol use is necessary to better understand the relationship between BIS\/BAS and alcohol\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70944","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:34:47Z","timestamp":1761024887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Relationship Between Behavioral Inhibition and Approach Systems and Alcohol\u2010Related Outcomes in People With Alcohol Use Disorder"],"prefix":"10.1002","volume":"15","author":[{"given":"Madeline E.","family":"Crozier","sequence":"first","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute On Drug Abuse Intramural Research Program and National Institute On Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research National Institutes of Health  Baltimore and Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute On Drug Abuse Intramural Research Program and National Institute On Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research National Institutes of Health  Baltimore and Bethesda Maryland USA"},{"name":"Center For Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health Brown University  Providence Rhode Island USA"},{"name":"Division of Addiction Medicine, Department of Medicine, School of Medicine Johns Hopkins University  Baltimore Maryland USA"},{"name":"Department of Neuroscience Georgetown University Medical Center  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4212","authenticated-orcid":false,"given":"Mehdi","family":"Farokhnia","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute On Drug Abuse Intramural Research Program and National Institute On Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research National Institutes of Health  Baltimore and Bethesda Maryland USA"},{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.95.8s2.9.x"},{"key":"e_1_2_9_3_1","volume-title":"The Alcohol Use Disorders Identification Test: Guidelines for use in Primary Health Care","author":"Babor T. 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