{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:08:58Z","timestamp":1778742538359,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction:<\/jats:title>\n Efficient and cost\u2010effective diagnostic tools for supporting dementia assessment are increasingly important. We aimed to evaluate whether providing neuroradiologists with volumetric data from an automatic MRI software, NeuroQuant, enhanced the diagnostic accuracy of their visual MRI assessment.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Two neuroradiologists assessed brain MRIs from 366 patients (mean age 67.5 years, SD 9.2, and 52% females) with subjective cognitive decline (SCD,\n n<\/jats:italic>\n 79), mild cognitive impairment (MCI,\n n<\/jats:italic>\n 86), or dementia (\n n<\/jats:italic>\n 201). The MCI and dementia patients were further diagnosed according to an etiology of Alzheimer's disease (AD,\n n<\/jats:italic>\n 217) versus non\u2010AD (\n n<\/jats:italic>\n 70). In random order the neuroradiologists visually evaluated medial temporal lobe atrophy (MTA, scale 0\u20134) with and without having access to the NeuroQuant report of age and sex adjusted volumetric percentiles of the hippocampus. Receiver operating characteristics (ROCs) analyses were conducted to calculate the area under the curves (AUCs) for the visual MTA, the automated NeuroQuant percentile, and the combined NeuroQuant\u2010assisted MTA in discriminating dementia from SCD and AD from non\u2010AD.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The AUC of the visual MTA for dementia versus SCD discrimination increased slightly but not significantly when the neuroradiologists were provided with NeuroQuant results (AUC 0.76\u20130.79,\n p<\/jats:italic>\n 0.28). Yet, the isolated NeuroQuant evaluation reached the highest accuracy (AUC 0.85,\n p<\/jats:italic>\n \u00a0<\u00a00.001), significantly better than the MTA assessment (\n p<\/jats:italic>\n 0.002) and the NeuroQuant\u2010assisted MTA (\n p<\/jats:italic>\n 0.04). Only the isolated NeuroQuant assessment discriminated AD from non\u2010AD (AUC 0.60,\n p<\/jats:italic>\n 0.006).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n On the basis of our findings, we suggest an increased use of clinically approved automatic volumetry methods in radiological departments.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.70948","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:47:40Z","timestamp":1759218460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Automatic MRI Volumetry Assisted Visual Assessment of the Medial Temporal Lobe in Clinical Dementia Work\u2010Up"],"prefix":"10.1002","volume":"15","author":[{"given":"Karin","family":"Persson","sequence":"first","affiliation":[{"name":"The Norwegian National Centre for Ageing and Health Vestfold Hospital Trust T\u00f8nsberg Norway"},{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke F. M.","family":"Rhodius\u2010Meester","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"},{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine Holt","family":"Edwin","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Brita","family":"Knapskog","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bekkhus\u2010Wetterberg","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Selb\u00e6k","sequence":"additional","affiliation":[{"name":"The Norwegian National Centre for Ageing and Health Vestfold Hospital Trust T\u00f8nsberg Norway"},{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Engedal","sequence":"additional","affiliation":[{"name":"The Norwegian National Centre for Ageing and Health Vestfold Hospital Trust T\u00f8nsberg Norway"},{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Schellhorn","sequence":"additional","affiliation":[{"name":"Division of Radiology and Nuclear Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2020.04.004"},{"key":"e_1_2_10_4_1","unstructured":"CorTechs Labs. Inc. 2023 \u201cThe NeuroQuant Normative Database.\u201d White Paper.CorTechs Labs. 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