{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:06:25Z","timestamp":1789981585890,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Prion diseases are fatal neurodegenerative disorders of the central nervous system. Sporadic Creutzfeldt\u2013Jakob disease (sCJD) is the most encountered form of the disease. The mean survival time is less than a year after diagnosis. Sleep problems are common in CJD. However, only a few studies revealed sleep pathology of CJD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Between 2013 and 2023, patients diagnosed with probable CJD who had video electroencephalography (EEG) and polysomnography (PSG) studies were evaluated. Detailed examination of the first and last EEGs (if any) was based on background activity, slow wave paroxysms, epileptiform discharges, and additional findings. Macro\u2010 and microstructure of sleep and sleep disturbances were evaluated with PSG studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients (two females, five males) at the mean age of 60 years were analyzed. Gait disturbances, difficulty in speech, and visual problems were common in addition to progressive cognitive impairment. Neurological examination revealed ataxia, dysarthria, myoclonus and\/or aphasia, and loss of vision. Typical 1\u00a0Hz generalized periodic discharges and slow wave activity on the background were encountered in the advanced stage of the disease. Sleep\u2010related problems were reported by three patients (42.8%); however, when we questioned carefully, we realized all patients had sleep disturbances such as simple or complex movements during sleep, sleep vocalizations, insomnia, and daytime sleepiness simultaneously with the main symptom. During PSG recording, sleep\u2010related apnea and insomnia were frequently reported. Interestingly, one patient had an initial de novo finding of Cheyne\u2013Stokes apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sleep problems such as insomnia or apnea could be the first sign of CJD. It should be carefully questioned of every patient and caregiver. PSG may help to specify prognostic and clinical differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70971","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:27:01Z","timestamp":1765981621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prodromal Sleep Disturbances and Polysomnographic Findings in Patients With Creutzfeldt\u2013Jakob Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6052","authenticated-orcid":false,"given":"Ezgi","family":"Demirel","sequence":"first","affiliation":[{"name":"Department of Neurology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-7939","authenticated-orcid":false,"given":"Gul","family":"Yalcin\u2010Cakmakli","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-3660","authenticated-orcid":false,"given":"Ezgi","family":"Yetim","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-7138","authenticated-orcid":false,"given":"Serap","family":"Saygi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8575-9574","authenticated-orcid":false,"given":"Fadime Irsel","family":"Tezer","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58040473"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)91111-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336896.2021.1968291"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7593-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0252"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/155005949202300305"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06147-z"},{"issue":"1","key":"e_1_2_12_10_1","first-page":"113","article-title":"Central Apnea in a Sporadic Case of Creutzfeldt\u2013Jakob Disease With Brainstem Involvement","volume":"110","author":"Gascon\u2010Bayarri J.","year":"2010","journal-title":"Acta Neurologica Belgica"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12405"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.09.004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30477-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.07.010"},{"issue":"1","key":"e_1_2_12_15_1","first-page":"1","article-title":"Sleep in Neurodegenerative Diseases","volume":"11","author":"Iranzo A.","year":"2016","journal-title":"Sleep Medicine"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2006.00723.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5944"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","unstructured":"Kang P. G.De Bruin L.Wang M.Lim B.Ances andB.Bucelli.2016a. \u201cThe Spectrum of Sleep Pathology in Definite Creutzfeldt\u2013Jakob Disease (P4.282).\u201d Neurology 86 no. 16_supplement: P4.282.","DOI":"10.1212\/WNL.86.16_supplement.P4.282"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"651","article-title":"Serial Polysomnograms in Creutzfeldt\u2013Jakob Disease","volume":"41","author":"Kazukawa S.","year":"1987","journal-title":"Japanese Journal of Psychiatry and Neurology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.163733"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63945-5.00013-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210445.16135.56"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000136225.80445.C9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-001197"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00323-5"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11051135"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2022-0315"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880151103"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00653.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.05.014"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-022-01199-2"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2019.100212"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S319917"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.362"},{"issue":"10","key":"e_1_2_12_36_1","first-page":"849","article-title":"Precocious Loss of Physiological Sleep in a Case of Creutzfeldt Jakob Disease: A Serial Polygraphic Study","volume":"18","author":"Terzano M. G.","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-05-01869.1997"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/380639a0"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01008.2015"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S322426"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103086"},{"key":"e_1_2_12_42_1","first-page":"155","volume-title":"Handbook of Clinical Neurology","author":"Zerr I.","year":"2018"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6657724"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01897-y"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00310"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.70971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:43:57Z","timestamp":1789980237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/brb3.70971"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70971","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70971\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70971\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70971\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70971\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70971\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70971\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70971"}}