{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:09:05Z","timestamp":1778742545560,"version":"3.51.4"},"reference-count":85,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31\u201061857.00"],"award-info":[{"award-number":["31\u201061857.00"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310000\u2010110005"],"award-info":[{"award-number":["310000\u2010110005"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B\u2010149643"],"award-info":[{"award-number":["310030B\u2010149643"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A\u2010132465"],"award-info":[{"award-number":["31003A\u2010132465"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030\u2010160229"],"award-info":[{"award-number":["320030\u2010160229"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A pilot study provided preliminary evidence indicating that peri\u2010lesional adult autologous neural cell ecosystem transplantation (so\u2010called ANCE) can enhance the functional recovery of manual dexterity in macaque monkeys following a unilateral lesion of the hand representation in the primary motor cortex (M1). As compared to five untreated control animals subjected to M1 lesions, the improvement of functional recovery was observed in our pilot study in two ANCE\u2010treated monkeys (also M1 lesioned). To strengthen these promising preliminary results, the present study aimed at introducing two additional ANCE monkeys, as well as one new control monkey, all subjected to M1 lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Manual dexterity was assessed based on the modified Brinkman board task, performed with the contralesional hand to retrieve small food pellets from slots using the precision grip (opposition of thumb and index finger).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As with the two pilot ANCE\u2010treated monkeys, the two new ANCE\u2010treated monkeys exhibited a rebound of functional recovery (a second plateau) associated to the treatment (after approximately 2\u20133 months delay post\u2010treatment), following a first plateau of spontaneous recovery. In contrast, all control monkeys (\n                      <jats:italic>n<\/jats:italic>\n                      = 6) exhibited a single plateau of functional recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study confirms that ANCE treatment significantly improves functional recovery from motor cortex lesions in adult macaques, with performance gains ranging from 20% to 40%. These findings support a possible future initiative to initiate clinical trials based on ANCE therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70986","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:00:32Z","timestamp":1760594432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys"],"prefix":"10.1002","volume":"15","author":[{"given":"Camille","family":"Roux","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition University of Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Savidan","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition University of Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Brunet","sequence":"additional","affiliation":[{"name":"Cell Production Center (CPC) Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-6019","authenticated-orcid":false,"given":"Eric M.","family":"Rouiller","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition University of Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Schmidlin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition University of Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Kaeser","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition University of Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010016\u20101268\u2010z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.036545"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010011\u20100327\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23579"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22547"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20100460.1000383"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319850133"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22353"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00398-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp136"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp084"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2003.08.005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909X470847"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.04.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2023.102537"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2022.08.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.160"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00382"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0904\u201018.2018"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1595"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3256\u201005.2005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00792.2006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53355-5.00015-4"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010024\u201006949\u2010x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109384(02)00929\u20100"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16\u201020\u201006513.1996"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14074"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2019.00050"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1436"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2009.06642.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000115\u2010w"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113540"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010012\u20103262\u2010x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13\u201003\u201000952.1993"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15\u201005\u201003284.1995"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70039\u2010X"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00101"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2013.10.008"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820c02c0"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.46867\/ijcp.2014.27.02.04"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.05.025"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00459.2009"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990229770980"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.023"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.70110"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11206"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/91.1.1"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17445.1"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125547"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050830"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.297060"},{"key":"e_1_2_12_53_1","first-page":"219","article-title":"The Organization of the Frontal Motor Cortex","volume":"15","author":"Luppino G.","year":"2000","journal-title":"News in Physiological Sciences: an International Journal of Physiology Produced Jointly By the International Union of Physiological Sciences and the American Physiological Society"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.3.281"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1605144"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22218"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2226\u201019.2020"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN\u2010190910"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.02.005"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3109\/08990220.2010.485963"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN\u2010160661"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/08990220.2013.790806"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0196\u201021.2021"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23861"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24706"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1737\u201014.2015"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01001.2007"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.03.010"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.04.015"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00354.2007"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315619701"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1452\u201022.2023"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808362106"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci\u20102022\u20100342"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.1996.tb01592.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.1998.00075.x"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.06.018"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0944\u201008.2008"},{"key":"e_1_2_12_79_1","first-page":"3258","article-title":"Behavioral Assessment of Manual Dexterity in Non\u2010Human Primates","volume":"57","author":"Schmidlin E.","year":"2011","journal-title":"Journal of Visual Experiments"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.646224"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN\u2010130344"},{"issue":"3","key":"e_1_2_12_82_1","first-page":"298","article-title":"Angiogenesis, Neurogenesis and Brain Recovery of Function Following Injury","volume":"11","author":"Xiong Y.","year":"2010","journal-title":"Current Opinion in Investig Drugs"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.04.005"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16674487"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.07.005"},{"issue":"201","key":"e_1_2_12_86_1","first-page":"1","article-title":"Mesenchymalderived Extracellular Vesicles Enhance Microgliamediated Synapse Remodeling After Cortical Injury in Aging Rhesus Monkeys","volume":"20","author":"Zhou Y.","year":"2023","journal-title":"Journal of Neuroinflammation"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.70986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:27:19Z","timestamp":1778740039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/brb3.70986"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70986","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70986"}}