{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:56:17Z","timestamp":1786636577774,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traumatic brain injury harms health, causes disability, and burdens health care systems and economies. Although new treatments for brain injury have been developed, their therapeutic efficacy remains insufficient. Herein, we demonstrate the therapeutic efficacy of artificial dura mater with varying basic fibroblast growth factor (bFGF)\u2010releasing capabilities using a brain injury model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Artificial dura mater of lower (FGF\u2010L) and higher (FGF\u2010H) bFGF\u2010releasing capabilities was prepared via oxygen plasma treatment for polyglycolic acid nonwoven fabric followed by bFGF adsorption. Mice received either bFGF\u2010releasing dura mater (FGF\u2010L, FGF\u2010H) or bFGF\u2010free dura mater (FGF\u2010C) at the site of the induced brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neurological functions significantly improved in the FGF\u2010L and FGF\u2010H groups compared with those in the FGF\u2010C group on Day 14. No significant difference was observed in the brain injury area between the FGF\u2010C group and either the FGF\u2010L or FGF\u2010H group. The number of SRY\u2010box transcription factor 2\u2010positive cells in the cortex was significantly larger in the FGF\u2010L and FGF\u2010H groups than in the FGF\u2010C group on Day 7. The terminal transferase dUTP nick\u2010end labeling\u2010positive cell ratio was significantly lower in the FGF\u2010H group than in the FGF\u2010C group on Day 14. The occludin\u2010positive and ZO\u20101\u2010positive cell ratios were significantly greater in the FGF\u2010H group than in the FGF\u2010C group on Day 14, suggesting improved blood\u2013brain barrier integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The bFGF\u2010releasing dura mater enhanced neural progenitor cell proliferation, inhibited apoptosis and blood\u2013brain barrier breakdown, and contributed to neurological function recovery in brain\u2010injured mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71008","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:11:58Z","timestamp":1761804718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Basic Fibroblast Growth Factor\u2010Releasing Bioabsorbable Polyglycolic Acid Dura Mater 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