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Although substantial progress has been made in understanding \u03b1\u2010syn pathology, a comprehensive bibliometric evaluation of global trends in this field remains lacking. This study aims to systematically map the research landscape surrounding \u03b1\u2010syn aggregation and propagation in PD, offering insights into its molecular mechanisms and clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bibliometric analysis was conducted using data retrieved from the Web of Science Core Collection (WoSCC) spanning 2005 to 2024. The data were processed and analyzed with R\u2010Bibliometrix, VOSviewer, and CiteSpace to quantify publication trends, international collaborations, influential authors and institutions, journal impact, and keyword co\u2010occurrence networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3220 relevant articles were identified. The number of annual publications steadily increased, reflecting growing scholarly interest. The United States, China, and the United Kingdom emerged as leading contributors. Robust international collaborations were observed, especially among Western countries, with the University of California System identified as the most prolific institution. Two primary thematic clusters were revealed: (1) \u201caggregation,\u201d focusing on the roles of \u201cmitochondria\u201d and \u201clysosomes,\u201d and (2) \u201cpropagation,\u201d highlighting the involvement of \u201cexosomes\u201d and \u201cmicroglia.\u201d Emerging research frontiers included \u201cbiomarkers\u201d and \u201cneuroinflammation,\u201d with a recent trend shifting toward studies on the propagation of \u03b1\u2010syn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study underscores a paradigm shift in PD research from \u03b1\u2010syn aggregation to propagation, emphasizing the significance of exosomes, microglia, and systemic inflammation in disease pathogenesis. These findings provide a comprehensive roadmap for future research, highlighting the need for interdisciplinary collaboration and the development of targeted therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71023","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:27:21Z","timestamp":1761805641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aggregation and Propagation of \u03b1\u2010Synuclein in Parkinson's Disease: A Bibliometric Perspective"],"prefix":"10.1002","volume":"15","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai Research Institute for Intelligent Autonomous Systems, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine Tongji University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhao","family":"Ma","sequence":"additional","affiliation":[{"name":"Center For Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Gao","sequence":"additional","affiliation":[{"name":"Center For Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Anesthesiology and Brain Functional 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