{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:54:33Z","timestamp":1786636473061,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is a fast\u2010growing neurodegenerative disease causing a high burden on national health systems. There is a lack of contemporary, reliable epidemiological data for PD in Germany. The aim of this study was to estimate the incidence and prevalence of PD in Germany for the years 2016\u20132021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a secondary data analysis of anonymized health claims data from a subset of German statutory health insurances (SHIs) for the years 2016\u20132021. Data were then extrapolated to represent the full SHI population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2016 to 2021, PD prevalence in the study population increased from 494 to 511 patients per 100,000 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0067). Incident patients showed no change overall but notably decreased from 2019 to 2020. In contrast, PD prevalence in the extrapolated cohort declined significantly during the same period, dropping from 575 to 501 patients per 100,000 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Similarly, PD incidence decreased from 69 to 60 patients per 100,000 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD prevalence increased in the study population but declined in the extrapolated cohort, while incidence remained stable overall in the study population, yet decreased in the extrapolated cohort. This study provides key insights into the epidemiology of PD in Germany, highlighting the influence of methodology and the need for ongoing monitoring to inform healthcare planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71027","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:35:24Z","timestamp":1762410924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology of Parkinson's Disease in Germany Between 2016 and 2021 Based on Statutory Health Insurance Claims Data"],"prefix":"10.1002","volume":"15","author":[{"given":"Dirk","family":"Woitalla","sequence":"first","affiliation":[{"name":"Department of Neurology St. Josef\u2010Krankenhaus Kupferdreh  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisa","family":"Ellrichmann","sequence":"additional","affiliation":[{"name":"Faculty of Health\/School of Medicine, Chair of Neurology II Witten\/Herdecke University  Witten Germany"},{"name":"Department of Neurology Klinikum Dortmund gGmbH  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Jun","family":"Groiss","sequence":"additional","affiliation":[{"name":"Neuro\u2010Centrum D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Walzer","sequence":"additional","affiliation":[{"name":"MArS Market Access &amp; Pricing Strategy GmbH  Weil am Rhein Germany"},{"name":"State University Baden\u2010Wuerttemberg  Loerrach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz\u2010Michael","family":"Vollmer","sequence":"additional","affiliation":[{"name":"MArS Market Access &amp; Pricing Strategy GmbH  Weil am Rhein Germany"},{"name":"University of T\u00fcbingen, Geoinformatics  T\u00fcbingen Germany"},{"name":"University of Applied Sciences Rottenburg\/Neckar  Rottenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Thiesen\u2010Nash","sequence":"additional","affiliation":[{"name":"BIAL Deutschland GmbH  M\u00f6rfelden\u2010Walldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-5380","authenticated-orcid":false,"given":"Sebastian","family":"Krenberger","sequence":"additional","affiliation":[{"name":"MArS Market Access &amp; Pricing Strategy GmbH  Weil am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Borchert","sequence":"additional","affiliation":[{"name":"WIG2 GmbH  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4201-5886","authenticated-orcid":false,"given":"Glynn","family":"Harrison\u2010Jones","sequence":"additional","affiliation":[{"name":"BIAL Pharma UK Ltd.  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