{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:06:32Z","timestamp":1789981592407,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have addressed the burden of neurological disorders in Greenland (GL). We aim to estimate nationwide incidences and prevalence of a broad group of neurological disorders in the total Greenlandic population and according to ethnicity (Inuit, Non\u2010Inuit). To explore the importance of ethnic and environmental factors we estimated corresponding rates among Inuit and Non\u2010Inuit living in Denmark (DK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A long\u2010standing collaboration between the Danish and Greenlandic healthcare system enabled us to follow the Greenlandic and Danish population for dementia, Parkinson's Disease (PD), epilepsy, stroke, and infections of the Central Nervous System using national registries from both countries. Incidence rates (IRs) were calculated using log linear Poisson\u2010regression for the combined period 1987\u20102014, and stratified according to ethnicity, country of residence and periods. Age\u2010standardized IRs (ASIRs) were based on the WHO 2000\u20132025 standard population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Greenlandic IRs of epilepsy and ischemic stroke were 98.6 (95% CI: 93.8\u2013104) and 118 (95% CI: 113\u2013124) respectively, per 100,000 person\u2010years of risk. IRs for the remaining neurological disorders were below 40 per 100,000. During follow\u2010up we observed an increase in IRs of ischemic stroke and a less pronounced for dementia. Apart from dementia, ASIRs of neurological disorders were generally higher in the Greenlandic population compared with the Danish, most pronounced for subarachnoid hemorrhage (ASIR\n                      <jats:sub>GL<\/jats:sub>\n                      \/ASIR\n                      <jats:sub>DK\u00a0<\/jats:sub>\n                      =\u00a02.36 (2.12\u20132.62)). Inuit in Greenland were at a lower risk of stroke, PD and especially dementia (ASIR\n                      <jats:sub>GL<\/jats:sub>\n                      \/ASIR\n                      <jats:sub>DK\u00a0<\/jats:sub>\n                      =\u00a00.40 (0.35\u20130.46)) compared with Inuit in Denmark. The most prevalent neurological disorders in Greenland in 2014 were stroke and epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study emphasizes that stroke and epilepsy are important causes of morbidity in Greenland and suggests that dementia may become a challenge. Noticeable differences according to ethnicity and country of residence warrants further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71086","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:10:18Z","timestamp":1766473818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe Neurological Disorders in the Greenlandic Population: A Nationwide Register\u2010Based Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Nete","family":"Munk Nielsen","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"},{"name":"Focused Research Unit in Neurology, Department of Neurology Hospital of Southern Jutland, University of Southern Denmark  Aabenraa Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-5222","authenticated-orcid":false,"given":"Melinda","family":"Magyari","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Rigshospitalet  Copenhagen Denmark"},{"name":"Danish Multiple Sclerosis Center, Department of Neurology University of Copenhagen, Rigshospitalet  Copenhagen Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Koch\u2010Henriksen","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon","family":"Stenager","sequence":"additional","affiliation":[{"name":"Focused Research Unit in Neurology, Department of Neurology Hospital of Southern Jutland, University of Southern Denmark  Aabenraa Denmark"},{"name":"Multiple Sclerosis Clinic of Southern Jutland (Aabenraa, Kolding, Esbjerg), Department of Neurology, Aabenraa Hospital of Southern Jutland, University of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention Statens Serum Institut  Copenhagen Denmark"},{"name":"Department of Infectious Diseases Rigshospitalet University Hospital  Copenhagen Denmark"},{"name":"Ilisimatusarfik University of Greenland  Nuussuaq Greenland"},{"name":"Department of Internal Medicine Queen Ingrid's Hospital  Nuuk Greenland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Age Standardization of Rates: A New WHO Standard","author":"Ahmad O. 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