{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:06:07Z","timestamp":1789981567983,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["HTA Project: 15\/57\/143"],"award-info":[{"award-number":["HTA Project: 15\/57\/143"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with progressive multiple sclerosis (pwPMS), who typically have established lower limb dysfunction, experience greater disability from upper limb dysfunction (ULD). The 9\u2010hole peg test (9HPT) is the primary clinical measure for ULD but does not fully capture the patient experience. The ABILHAND\u201023 is a well\u2010validated patient\u2010reported outcome measure (PROM) that evaluates bimanual ability in daily function. However, no large\u2010scale studies have assessed if the 9HPT reflects the individual ULD experience in pwPMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We sought to (van Munster et\u00a0al. 2023) assess the associations between the ABILHAND\u201023 and 9HPT, and (Huertas\u2010Hoyas et\u00a0al. 2020) to assess the ability of the 9HPT and other relevant covariables to predict ABILHAND\u201023 scores, using baseline data from the MS\u2010STAT2 trial, a phase 3 study on simvastatin for secondary progressive MS (SPMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional analysis of baseline data from the UCLH cohort of the MS\u2010STAT2 trial was performed using multiple linear regression to predict ABILHAND\u201023 logit scores by 9HPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      225 participants were analyzed. ABILHAND\u201023 scores moderately correlated with the 9HPT (rho = 0.47). Regression analysis showed that better 9HPT performance modestly predicted ABILHAND\u201023 logits (\u03b2 = \u20130.05, SE 0.008,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 9HPT only modestly predicts the ABILHAND\u201023 but does not fully capture the individual's daily disability experience, underscoring the value of patient\u2010reported outcome measures (PROMs) like the ABILHAND\u201023 in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71101","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:50:17Z","timestamp":1764222617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The ABILHAND\u201023 Patient Reported Outcome Measure in Secondary Progressive Multiple Sclerosis: A Cross\u2010Sectional Analysis With the Nine Hole Peg Test"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-7823","authenticated-orcid":false,"given":"Sean","family":"Apap Mangion","sequence":"first","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-7566","authenticated-orcid":false,"given":"Charles","family":"Wade","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-0177","authenticated-orcid":false,"given":"Tom","family":"Williams","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana De","family":"Angelis","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-1801","authenticated-orcid":false,"given":"Sarah","family":"Wright","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-4498","authenticated-orcid":false,"given":"Nevin","family":"John","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"},{"name":"Department of Medicine, School of Clinical Sciences Monash University  Clayton Australia"},{"name":"Department of Neurology Monash Health  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Doshi","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Calvi","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obioma","family":"Oraluzume","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Leibowitz","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Blackstone","sequence":"additional","affiliation":[{"name":"Comprehensive Clinical Trials Unit University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Braisher","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Favarato","sequence":"additional","affiliation":[{"name":"Department of Statistics, Institute of Child Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nicholas","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine Centre of Global Change and Health Medical Statistics  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neurorehabilitation The National Hospital for Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Chataway","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London UK"},{"name":"National Institute for Health and Care Research, Biomedical Research Centre University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The UCL MS\u2010STAT2 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"RUMM2030: A Windows Program for the Analysis of Data According to Rasch Unidimensional Models for Measurement","author":"Andrich D.","year":"2010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006532"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514549396"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512462919"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-086414"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14059"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520930985"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516638941"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.03.149"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517690824"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","unstructured":"Fiorini S. A.Verri A.Tacchino M.Ponzio G.Brichetto andA.Barla.2015. \u201cA Machine Learning Pipeline for Multiple Sclerosis Course Detection From Clinical Scales and Patient Reported Outcomes.\u201d in2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).","DOI":"10.1109\/EMBC.2015.7319381"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pri.1600"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103160"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11801-3"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13120"},{"issue":"1","key":"e_1_2_13_17_1","first-page":"S10","article-title":"Putting the Alzheimer's Cognitive Test to the Test II: Rasch Measurement Theory","volume":"9","author":"Hobart J.","year":"2013","journal-title":"Alzheimer's and Dementia"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0586-5"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70290-9"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.31"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6193938"},{"key":"e_1_2_13_22_1","first-page":"S41","article-title":"Performance Measures for Upper Extremity Functions in Persons With Multiple Sclerosis","volume":"55","author":"Kahraman T.","year":"2018","journal-title":"Noropsikiyatri Arsivi"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011123"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104433"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506070768"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5583063"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70264-9"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(98)90167-8"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.20.06446-1"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.11.035"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15560"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221105465"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2021-069"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509359922"},{"key":"e_1_2_13_35_1","unstructured":"World Medical Association.Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects.https:\/\/www.wma.net\/policies\u2010post\/wma\u2010declaration\u2010of\u2010helsinki\u2010ethical\u2010principles\u2010for\u2010medical\u2010research\u2010involving\u2010human\u2010subjects\/."},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585241288393"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103757"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:44:18Z","timestamp":1789980258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/brb3.71101"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71101","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.71101\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71101\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71101"}}