{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:06:08Z","timestamp":1789981568150,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Poststroke cognitive impairment (PSCI) is a common functional disorder that occurs following stroke, but there are few effective therapies. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulatory technique that has been used to improve cognitive function in stroke patients. Despite its widespread use in clinical research, the underlying mechanisms of rTMS are largely unknown. This study hypothesized that rTMS ameliorates PSCI by regulating white matter injury, which is of vital importance in cerebral ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>An ischemic stroke rat model was created using transient middle cerebral artery occlusion. The extents of brain damage and white matter injury, including diffusion tensor imaging and diffusion tensor tractography, were evaluated using MRI. Behavioral tests, including the modified neurological severity score test and Morris water maze test, were also used. In addition, we preliminarily explored the potential role of SDF\u20101\u03b1\/CXCR4 by Western blot analysis and real\u2010time reverse transcription PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>The results showed that 10\u00a0Hz rTMS promoted neurological recovery and cognitive deficits in ischemic rats. Additionally, 10\u00a0Hz rTMS alleviated cerebral infarct severity and attenuated white matter lesions. Furthermore, the expression levels of components of the SDF\u20101\u03b1\/CXCR4 axis influenced the effect of rTMS on ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This research provides further evidence that 10\u00a0Hz rTMS can alleviate white matter injury in affected brain regions and improve PSCI after ischemic stroke, potentially through the activation of the SDF\u20101\u03b1\/CXCR4 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71117","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:02:32Z","timestamp":1765177352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repetitive Transcranial Magnetic Stimulation Improves Cognitive Impairment via the Regulation of White Matter Injury in Rats With Ischemic Stroke"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaoxia","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21622965.2019.1613993"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03102-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00226"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11250"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0770-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121204"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.1005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114242"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00590"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10469"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9397-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00277-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101919"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1177594"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.04.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00559"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6238575"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.09.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/156489"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S343906"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205019666220802151945"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03161-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.07.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01747-y"},{"key":"e_1_2_10_26_1","article-title":"Towards Targeted Brain Stimulation in Stroke: Connectivity as a Biomarker of Response","volume":"12","author":"Hordacre B.","year":"2018","journal-title":"Journal of Experimental Neurology"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211029197"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00160"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.10.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0074"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_10_32_1","first-page":"6","article-title":"The Neuroblast and Angioblast Chemotaxic Factor SDF\u20101 (CXCL12) Expression Is Briefly Up Regulated by Reactive Astrocytes in Brain Following Neonatal Hypoxic\u2010Ischemic Injury","volume":"6","author":"Miller J. T.","year":"2005","journal-title":"BMC Neuroscience [Electronic Resource]"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488409"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.12.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021981"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00253"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094694"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014356"},{"key":"e_1_2_10_39_1","first-page":"89","article-title":"Clinically Accessible Neuroimaging Predictors of Post\u2010Stroke Neurocognitive Disorder: A Prospective Observational Study","volume":"21","author":"Schellhorn T.","year":"2021","journal-title":"BMC Neurology [Electronic Resource]"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1197422"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9102-9"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001227"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-019-01150-2"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01924-5"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.807585"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.834329"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10021"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13360"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718802755"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04917"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.31083\/JIN-170043"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.05.019"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-022-00689-8"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:44:48Z","timestamp":1789980288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/brb3.71117"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71117","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71117"}}