{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:07:12Z","timestamp":1789981632282,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Research has documented a high prevalence of cognitive and affective impairments in individuals with spinal cord injury (SCI). However, the molecular mechanisms underlying these deficits remain poorly understood. In this study, to investigate the molecular basis of cognitive and affective dysfunctions following SCI, we examined the role of calcium\/calmodulin\u2010dependent kinase II (CaMKII) activation, with a specific focus on its phosphorylated form (pCaMKII), using a rat model of SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Experimental results demonstrated that SCI led to spatial memory deficits as well as depression\u2010 and anxiety\u2010like behaviors, as evidenced by performance in the Morris water maze (MWM), elevated plus maze (EPM), and forced swim test (FST). Compared to the sham group, increased levels of pCaMKII were observed in the medial prefrontal cortex (mPFC) at Day 56 after SCI. Moreover, inhibiting CaMKII phosphorylation via microinjection of KN\u201093\u2014a CaMKII activation inhibitor\u2014into the mPFC alleviated depression\u2010like behavior and cognitive deficits, but not anxiety\u2010like behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finds and Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that CaMKII activation in the mPFC may play an important role in mediating negative emotional states following SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71118","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:42:21Z","timestamp":1765435341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of Calcium\/Calmodulin\u2010Dependent Kinase II in the Medial Prefrontal Cortex Mediates Spinal Cord Injury\u2010Related Cognitive and Affective Changes"],"prefix":"10.1002","volume":"15","author":[{"given":"Jian","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Orthopedics The 960th Hospital of PLA  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The 960th Hospital of PLA  Jinan China"},{"name":"Jinzhou Medical University, The 960th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force Postgraduate Training Base  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing Chaoyang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2025.149461"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR\u2010D\u201024\u201000434"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.115"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73557"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6673967"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaf051"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.03.004S1044\u20105323(14)00037\u20102"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2025.111475"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155595"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.12.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098180"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.06.005S0889\u20101591(11)00202\u20109"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00596"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.12094111091209411109"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3138nrn3138"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.182"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010014\u20108707\u20108"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201005152\u20105"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114220"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0190"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"Wang Y. L.Wang B.Yang et\u00a0al.2025. \u201cAlterations in Topological Structure and Modular Interactions in Pediatric Patients With Complete Spinal Cord Injury: A Functional Brain Network Study.\u201dJournal of Neurotrauma.https:\/\/doi.org\/10.1089\/neu.2024.0560.","DOI":"10.1089\/neu.2024.0560"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5110\u201013.2014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000393"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf186"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010022\u201000624\u20102"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002638\u20105"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.029"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000011593"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112070"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.08.057"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:44:26Z","timestamp":1789980266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/brb3.71118"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71118","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71118"}}