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As a core signaling pathway in the mammalian innate immune system, the cyclic GMP\u2010AMP synthase (cGAS)\u2010stimulator of interferon genes (STING) pathway plays a pivotal role in maintaining intracellular homeostasis. This review aims to systematically elucidate the role and therapeutic potential of the cGAS\u2010STING signaling pathway in AD, focusing on its involvement in key pathological processes and its relevance to AD risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Through literature search, we summarized the molecular mechanisms of the cGAS\u2010STING pathway and its dysregulation in AD, emphasizing the integrated evidence linking cGAS\u2010STING to neuroinflammation, autophagy impairment, and neuronal death, as well as its interactions with aging, obesity, cardiovascular disease, and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The cGAS\u2010STING pathway is critically involved in AD pathogenesis, contributing to neuroinflammation, defective autophagy, and neuronal loss. Its activation is associated with multiple AD risk factors, suggesting a broad influence on disease progression. Pharmacological inhibition of cGAS\u2010STING shows promise in attenuating these pathological features in preclinical models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The cGAS\u2010STING signaling pathway plays a central regulatory role in the central nervous system, and its dysregulation promotes neuroinflammation and is closely associated with AD. This pathway forms a vicious cycle by integrating multiple pathological signals, including mitochondrial dysfunction and endoplasmic reticulum stress. Small\u2010molecule inhibitors and natural products targeting this pathway have demonstrated significant efficacy in preclinical studies, providing a basis for developing disease\u2010modifying therapies for AD. Future efforts should focus on multi\u2010target combination strategies (e.g., STING inhibitors co\u2010administered with A\u03b2\/tau drugs) and dynamically deciphering pathway alterations across AD stages to advance personalized treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71130","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:04:38Z","timestamp":1765436678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role and Therapeutic Potential of the cGAS\u2010STING Signaling Pathway in Alzheimer's Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3593-9227","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3761-888X","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"Jiangsu College of Nursing  Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1469-3931","authenticated-orcid":false,"given":"Qiuyan","family":"Ye","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5090-6842","authenticated-orcid":false,"given":"Honglin","family":"Li","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"Department of Rehabilitation Medicine III The Second Affiliated Hospital of Heilongjiang University of Chinese 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