{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:59:14Z","timestamp":1791561554874,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171886"],"award-info":[{"award-number":["82171886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471158"],"award-info":[{"award-number":["82471158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Some patients with Charcot\u2010Marie\u2010Tooth disease (CMT) exhibit prolonged auditory brainstem response (ABR) latencies or abnormal waveforms, suggesting potential damage to the peripheral auditory nerve or central auditory pathways. Diffusion tensor imaging (DTI), a non\u2010invasive neuroimaging technique, can detect the integrity and functional properties of white matter structures with high sensitivity. However, research on the association between DTI characteristics and ABR changes in patients with CMT remains relatively limited, and whether both modalities reflect synergistic damage to central\u2010peripheral nerve axons or myelin sheaths remains unclear. In this study, we aimed to analyze cerebral white matter microstructural abnormalities in patients with CMT using DTI and explore their correlation with ABR, thereby exploring the pathophysiological mechanisms of the central auditory pathway in patients with CMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 14 patients with CMT and 14 healthy controls. DTI data were acquired using a 3.0T MRI scanner. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The latencies and interpeak latencies of the auditory pathway were measured using ABR. DTI metrics were compared between the two groups, and the relationship between DTI parameters and ABR results was analyzed in patients with CMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the healthy controls, patients with CMT exhibited significantly decreased FA values and significantly increased MD, AD, and RD values in brain regions\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), including the occipital part of the corona radiata, inferior longitudinal fasciculus, anterior thalamic radiation, and inferior fronto\u2010occipital fasciculus. ABR interpeak latencies correlated positively with FA in the left inferior longitudinal fasciculus and negatively with AD. Three participants did not complete the ABR test. ABR latencies in CMT patients were significantly correlated with AD values in the anterior thalamic radiation and corpus callosum (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal central white matter microstructure (axonal degeneration, demyelination) in patients with CMT may lead to auditory pathway dysfunction by impairing neural conduction efficiency. The multimodal correlation analysis of DTI and ABR provides new insights into the mechanism of central nervous system involvement in CMT, suggesting its potential as a clinical biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71142","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T19:05:07Z","timestamp":1769367907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["White Matter Microstructural Correlates of Auditory Brainstem Responses in Patients With Charcot\u2010Marie\u2010Tooth Disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Luhe Hospital Capital Medical University  Beijing China"},{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"An","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2298-3971","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-6544","authenticated-orcid":false,"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-1905","authenticated-orcid":false,"given":"Yuhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031911"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"Braathen G. 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