{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:06:47Z","timestamp":1789981607920,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Imaging diagnosis of mild cognitive impairment (MCI) has garnered increasing attention due to its critical role in the early detection of Alzheimer's disease (AD) and other dementias. This study presents a bibliometric analysis to elucidate global research trends, key contributors, thematic clusters, and emerging topics within the field of MCI imaging diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>English\u2010language publications related to MCI imaging were retrieved from the Web of Science Core Collection (WoSCC) from January 1999 to December 2024. Bibliometric analyses were performed using VOSviewer, CiteSpace, and R\u2010bibliometrix to evaluate co\u2010authorship networks, institutional collaborations, journal impact, keyword co\u2010occurrence, and burst trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>A total of 7,568 articles showed an average annual growth of 22.27%, with output surging after 2007 and peaking in 2024 (n = 762). The United States led in productivity and impact, ahead of China and Italy. Leading institutions were the University of California System, Vrije Universiteit Amsterdam, and the University of London, with key authors including Clifford R. Jack Jr., Ronald C. Petersen, and Philip Scheltens. Core journals were Neurology, Neuroimage, and Brain. Cluster analysis revealed four themes: functional and cognitive networks, biomarkers and pathology, structural imaging and computational diagnostics, and guidelines. Recent trendsc (AI) (e.g., machine learning, deep learning), while citation bursts indicate an evolution from early biomarker and imaging research toward current AI and multimodal imaging for improved diagnosis and risk prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric analysis provides a comprehensive overview of the evolving research landscape in MCI imaging diagnosis. The integration of advanced computational methodologies, particularly AI\u2010powered tools, is driving precision diagnostics and personalized medicine. These advancements hold significant potential to improve early detection, stratify risk, and inform therapeutic interventions, ultimately contributing to better outcomes for individuals with MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71144","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:13:47Z","timestamp":1766474027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging Diagnosis of Mild Cognitive Impairment: A Bibliometric Analysis (1999\u20132024)"],"prefix":"10.1002","volume":"15","author":[{"given":"Jianan","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Medical Imaging Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College) Shantou University Medical College  Shenzhen China"},{"name":"Guangdong Key Laboratory For Biomedical Measurements and Ultrasound Imaging, National\u2010Regional Key Technology Engineering Laboratory For Medical Ultrasound, School of Biomedical Engineering Shenzhen University  Shenzhen China"},{"name":"Department of Experiment and Research South China Hospital, Medical School,Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Li","sequence":"additional","affiliation":[{"name":"PET Center Zhongshan Hospital of Dalian University  Dalian China"},{"name":"Longgang Institute of Medical Imaging, Shantou University Medical College &amp; The Third People's Hospital of Longgang District, Shenzhen Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuncheng","family":"Li","sequence":"additional","affiliation":[{"name":"Longgang Institute of Medical Imaging, Shantou University Medical College &amp; The Third People's Hospital of Longgang District, Shenzhen Beijing China"},{"name":"Department of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Medical Imaging Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College) Shantou University Medical College  Shenzhen China"},{"name":"Shenzhen Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen, 518116  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001347"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119329"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101645"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30277\u20105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24782"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032886\u2010w"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S123428"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180119092427"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.4544"},{"issue":"9","key":"e_1_2_12_11_1","first-page":"S89","article-title":"White Matter Hyperintensities Are Higher among Early\u2010Onset Alzheimer's Disease Participants than Their Cognitively Normal and Early\u2010Onset nonAD Peers: Longitudinal Early\u2010Onset Alzheimer's Disease Study (LEADS)","volume":"19","author":"Eloyan A.","year":"2023","journal-title":"Alzheimers Dement"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205017666200303105016"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010022\u201004946\u2010x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1051482"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184869"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507655102"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/20298"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010023\u201009625\u20107"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3000"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001181\u20101"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317518791401"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207219"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1001598"},{"issue":"3","key":"e_1_2_12_26_1","article-title":"Structural Magnetic Resonance Imaging for the Early Diagnosis of Dementia Due to Alzheimer's Disease in People with Mild Cognitive Impairment","volume":"3","author":"Lombardi G.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105393"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(09)00407-3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.10.023"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000313"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212366"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010023\u201002565\u2010x"},{"key":"e_1_2_12_36_1","first-page":"724","article-title":"CiteSpace II: Visualization and Knowledge Discovery in Bibliographic Databases","volume":"2005","author":"Synnestvedt M. 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