{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:58:36Z","timestamp":1791561516199,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374008"],"award-info":[{"award-number":["82374008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sepsis\u2010associated encephalopathy (SAE) is a common neurological complication of sepsis. UMI\u201077 has shown unique benefits in modulating inflammation to improve sepsis. However, the exact role of UMI\u201077 in the treatment of SAE and its mechanism are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This article analyzes UMI\u201077 based on metabolomics and explores its mechanism of action in treating SAE based on the brain\u2010gut axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this study, hematoxylin and eosin (H&amp;E) and immunofluorescence staining were used to evaluate the therapeutic effect of UMI\u201077 on SAE mice. Applying untargeted metabolomics analysis, the metabolic changes in the brain and intestines of septic mice treated with UMI\u201077 were examined. Furthermore, Receiver Operating Characteristic (ROC) analysis was used to select predictive biomarkers for exploring the mechanism of UMI\u201077 in treating SAE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Sixty\u2010six significant biomarkers in the brain were found and selected with the aid of untargeted the metabolomic method. Metabolic pathway analysis indicates that these differential metabolites are mainly involved in the metabolism of linoleic acid, biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism. Seventy\u2010eight important biomarkers were identified and selected in the intestine; metabolic pathway analysis revealed that these differential metabolites were mainly involved in phenylalanine, tyrosine, and tryptophan biosynthesis, and biotin metabolism. L\u2010phenylalanine, L\u2010tyrosine, and 5\u2010hydroxy\u2010tryptophan are the most important metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UMI\u201077 plays a positive regulatory role in disrupting the gut microbiota of mice through pathways such as the biosynthesis of phenylalanine, tyrosine, and tryptophan, and can significantly improve neurological function and reduce apoptosis of brain tissue cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71175","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:36:42Z","timestamp":1768293402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["UMI\u201077 Ameliorates Lipopolysaccharide\u2010Induced Sepsis\u2010Associated Encephalopathy by Modulating the Brain\u2010Gut Axis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0390-0188","authenticated-orcid":false,"given":"Yu","family":"Ke","sequence":"first","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Shenyang China"},{"name":"Department of Pharmacy Taizhou Central Hospital (Taizhou University Hospital)  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5112-2942","authenticated-orcid":false,"given":"Cuicui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-9910","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Shenyang China"},{"name":"Department of Pharmacy Taizhou Central Hospital (Taizhou University Hospital)  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5097-049X","authenticated-orcid":false,"given":"Menglu","family":"Ni","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Shenyang China"},{"name":"Department of Pharmacy Taizhou Central Hospital (Taizhou University Hospital)  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-5965","authenticated-orcid":false,"given":"Yuting","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Shenyang China"},{"name":"Department of Pharmacy Taizhou Central Hospital (Taizhou University Hospital)  Taizhou 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