{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:59:03Z","timestamp":1791561543686,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>DYT1 dystonia is the most common inherited dystonia, but mouse models recapitulating the human genotype do not exhibit overtly dystonic movements. Because cortical and striatal plasticity are implicated in dystonia pathogenesis, we hypothesized that repetitive performance of a cortically\u2010dependent reach\u2010to\u2010grasp task would induce abnormal dystonia\u2010like movements in DYT1\u2010knock in (DYT\u2010KI) mice. The goal of these experiments was to test that hypothesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TorsinA \u0394E (DYT1\u2010KI) mutant mice and non\u2010transgenic littermates (control) were trained to perform a cortically\u2010dependent single pellet reach\u2010to\u2010grasp task using an automated skilled reach\u2010to\u2010grasp apparatus. Task performance and the presence of abnormal movements were manually scored by reviewers blinded to genotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six DYT1\u2010KI and five littermate control mice performed at least 500 skilled reaches per animal. There were no differences in success or fumble rate between DYT1\u2010KI and control mice. DYT1\u2010KI mice exhibited subtle abnormal limb shaking in five trials, but a similar movement occurred in one control mouse in one trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DYT1\u2010KI mice learn and perform skilled reach\u2010to\u2010grasp comparably to control mice without developing meaningful abnormal movements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71176","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:12:09Z","timestamp":1767237129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cortically Dependent Motor Training Does Not Induce Abnormal Movements in DYT1\u2010Knock In Mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Alexander T.","family":"Hodge","sequence":"first","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Michigan Neuroscience Institute University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Michigan Neuroscience Institute University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Molecular and Integrative Physiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Michigan Neuroscience Institute University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Molecular and Integrative Physiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K.","family":"Leventhal","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Michigan Neuroscience Institute University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Disease Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Biomedical Engineering University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology VA Ann Arbor Health System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2008.06315.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2010.03048.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.04590.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.11.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227239"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114221"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61591"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0153\u201021.2021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.54.9.1746"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.47.2.508"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.08.025"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105699"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21160"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000020714.48349.4e"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000017100.68294.52"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.12.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398\u2010262"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.11.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.9.1266"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10774"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025420\u2010x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100415"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22814"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.09.028"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.113844"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142483"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139606"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5604\u201009.2010"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.971980"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/dyst.2024.12125"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348879"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12712"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp194"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100209\u2010y"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201015835\u20102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.07.022"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10096"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.6039"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997\u201040"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08352"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010018\u20100234\u20105"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010022\u201001495\u20102"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0240\u201024.2024"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105511"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106453"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.02.042"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678\u00d7211005877"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.06.005"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.04.015"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0855\u201005.2005"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.52.3.529"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010022\u201001334\u20104"},{"key":"e_1_2_10_57_1","unstructured":"Sinha N.2025. \u201cNon\u2010Parametric Alternative of 2\u2010Way ANOVA (ScheirerRayHare).\u201d MATLAB Central File Exchange retrieved November 10 2025 https:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/96399\u2010non\u2010parametric\u2010alternative\u2010of\u20102\u2010way\u2010anova\u2010scheirerrayhare."},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.05.009"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032245"},{"issue":"5","key":"e_1_2_10_60_1","first-page":"273","article-title":"Motor Performance of Monkeys After Bilateral Partial and Total Cerebral Decortications","volume":"35","author":"Travis A. M.","year":"1956","journal-title":"American Journal of Physical Medicine"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166\u20104328(05)80042\u20107"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20104328(93)90022\u2010i"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114471"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.031"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2021.05.003"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024539"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120916"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.12.027"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:48:06Z","timestamp":1791560886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/brb3.71176"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71176","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71176"}}