{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:58:45Z","timestamp":1791561525298,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and assess the efficacy of a rehabilitation\u2013cognition integrated care (RCIC) program for elderly patients with lower limb fractures and mild\u2010to\u2010moderate cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 128 eligible patients during January 2023 to December 2024 were randomly allocated to conventional (\n                      <jats:italic>n<\/jats:italic>\n                      = 64) or integrated care group (\n                      <jats:italic>n<\/jats:italic>\n                      = 64). Both groups received 12 weeks of intervention. Outcomes, including Fugl\u2010Meyer Assessment (FMA), Berg Balance Scale (BBS), Montreal Cognitive Assessment (MoCA), Functional Independence Measure (FIM), and Hospital Anxiety and Depression Scale (HADS) scores, were compared. Serum neurotrophic and neuroinflammatory markers were analyzed pre\u2010 and post\u2010intervention. Complications, fall recurrence rates, and nursing satisfaction were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post\u2010intervention, both groups showed improved FMA, BBS, and FIM scores, with significantly greater improvement in the integrated care group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). HADS\u2010Anxiety (HADS\u2010A) and HADS\u2010Depression (HADS\u2010D) scores decreased significantly more in the integrated care group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The integrated care group demonstrated higher MoCA scores versus both its own baseline and the conventional care group post\u2010intervention (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Serum BDNF and GDNF levels increased significantly in the integrated care group compared to both time\u2010matched controls and its baseline (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), while S100\u2010\u03b2 and IL\u20106 levels decreased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The integrated care group had lower overall complication rates (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), comparable fall recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05), and higher nursing satisfaction (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The RCIC program significantly enhances motor function, balance, cognition, and psychological status while reducing complications and improving satisfaction in elderly fracture patients with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71184","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:57:33Z","timestamp":1768546653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rehabilitation\u2013Cognition Integrated Care Program for Elderly With Lower Limb Fractures and Cognitive Impairment: Development and Efficacy"],"prefix":"10.1002","volume":"16","author":[{"given":"Qinfen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Traumatology and Orthopedics The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics The First Affiliated Hospital of Lishui University  Lishui Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-093893"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.5.2412"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.16"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1454452"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00516-4"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"S7","article-title":"Measuring Balance in the Elderly: Validation of an Instrument","volume":"83","author":"Berg K. 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