{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:59:10Z","timestamp":1791561550287,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Posterior cerebral artery (PCA) stroke, while comprising a smaller proportion of ischemic strokes, often results in significant neurological deficits and poses distinctive therapeutic challenges. This study aims to systematically review and meta\u2010analyze the efficacy and safety of EVT compared with best medical management (BMM) in patients with PCA stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic searches of PubMed, Embase, and Scopus up to July 2025 identified studies comparing EVT and BMM for PCA stroke. Eligible studies included patients with PCA stroke, compared EVT with BMM, and reported at least one outcome of interest. Statistical analyses employed random or fixed\u2010effects models as appropriate; results are presented as odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12 studies were included, encompassing 39,525 patients (2,540 EVT; 37,075 BMM). EVT was associated with significantly increased odds of early neurological improvement (ENI) (OR 2.11, 95% CI 1.81\u20132.45), and greater reduction in NIHSS at 24 h (MD \u20131.30, 95% CI \u20131.89 to \u20130.71). There was no significant difference in visual field normalization and no difference in excellent functional outcome. EVT was associated with lower odds of achieving functional independence (mRS 0\u20132 at 90 days: OR 0.75, 95% CI 0.67\u20130.85), and significantly increased risks of symptomatic intracranial hemorrhage (OR 2.32, 95% CI 1.66\u20133.23) and mortality at 90 days (OR 1.86, 95% CI 1.47\u20132.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In PCA stroke, endovascular thrombectomy (EVT) confers early neurological recovery but does not improve long\u2010term functional independence and is associated with higher risks of symptomatic hemorrhage and mortality compared with BMM. While EVT may benefit selected patients, these results underscore the need for individualized treatment decisions and prospective randomized trials focused on PCA stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71194","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:51:42Z","timestamp":1767808302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endovascular Therapy Versus Best Medical Treatment in Posterior Cerebral Artery Stroke: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Umama","family":"Alam","sequence":"first","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Jinnah Medical and Dental College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4273-0827","authenticated-orcid":false,"given":"Shree","family":"Rath","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bhubaneswar  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazia","family":"Khattak","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Asad","family":"Asif","sequence":"additional","affiliation":[{"name":"Healing House Psychiatric Clinic  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monsurah Bisola","family":"Alatise","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy Cadi Ayyad University  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubaba","family":"Yunas","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Khan","sequence":"additional","affiliation":[{"name":"Saidu Medical College  Swat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Sijad","family":"Uddin","sequence":"additional","affiliation":[{"name":"NIMRA Institute of Medical Sciences, Jupudi  Vijayawada Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5929-2047","authenticated-orcid":false,"given":"Labannya","family":"Das Puja","sequence":"additional","affiliation":[{"name":"Sir Salimullah Medical College  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"Inamullah","sequence":"additional","affiliation":[{"name":"Saidu Medical College  Swat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Fatima","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumia","family":"Fatima","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazeela","family":"Bibi","sequence":"additional","affiliation":[{"name":"Jinnah Medical and Dental College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Moiz","sequence":"additional","affiliation":[{"name":"Bacha Khan Medical College  Mardan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Academic Clinical Lecturer Newcastle University  Newcastle UK"},{"name":"Department of Cardiology Freeman Hospital Newcastle upon Tyne UK"},{"name":"Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"A Revised Introduction to the R\u2010Index. |Replicability\u2010Index [Internet]. 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