{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:59:10Z","timestamp":1791561550201,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020627","name":"Kerman Neuroscience Research Center, Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["402000357"],"award-info":[{"award-number":["402000357"]}],"id":[{"id":"10.13039\/501100020627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a progressive and prevalent neurodegenerative disorder characterized by progressive cognitive decline and memory impairment. Intracerebroventricular (ICV) administration of streptozotocin (STZ) in rodents recapitulates key features of sporadic AD, including brain insulin resistance and oxidative stress. Dexmedetomidine (Dex), a highly selective \u03b12\u2010adrenergic receptor agonist, has demonstrated neuroprotective and anti\u2010inflammatory properties, suggesting its potential utility as a therapeutic approach for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy adult male Wistar rats were randomly allocated to seven experimental groups: Control, Sham, STZ, Sham + Dex (25\u00a0\u00b5g\/kg), and STZ + Dex (25, 50, 100\u00a0\u00b5g\/kg). Cognitive performance and anxiety\u2010like behaviors were evaluated using the open\u2010field test (OFT), elevated plus maze (EPM), Y\u2010maze test, and Morris water maze (MWM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the Y\u2010maze, STZ\u2010treated rats exhibited significant reductions in spontaneous alternation behavior (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), which were significantly reversed by Dex (25\u00a0\u00b5g\/kg,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). In the MWM, the STZ administration resulted in prolonged escape latencies and increased path lengths compared with Control animals (\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.05). Treatment with Dex (25\u00a0\u00b5g\/kg) significantly improved spatial learning and memory retention (\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.05). No significant differences were observed in locomotor activity and anxiety\u2010related behaviors in the OFT or EPM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that Dex at 25\u00a0\u00b5g\/kg attenuates STZ\u2010induced cognitive deficits, likely through neuroprotective and anti\u2010inflammatory mechanisms. The results highlight Dex as a promising candidate for AD therapy, though further research is required to elucidate its underlying molecular pathways. The study supports the potential repurposing of Dex for neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71196","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:59:54Z","timestamp":1767808794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dexmedetomidine on the Behavioral Outcomes in Streptozotocin\u2010Induced Alzheimer's Disease Rats"],"prefix":"10.1002","volume":"16","author":[{"given":"Mina","family":"Mohasel\u2010Roodi","sequence":"first","affiliation":[{"name":"Department of Anatomy, Afzalipour School of Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Nozari","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman 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