{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:48:48Z","timestamp":1791564528979,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Saliva, like other body fluids, has been investigated as a source of biomarkers for Alzheimer's disease (AD) due to its accessibility. Recently, decreased amyloid\u2010PET uptake in the salivary glands of patients with AD was reported, prompting interest in the potential clinical relevance of that finding. This study evaluates the association between salivary gland uptake on\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>8<\/jats:sup>\n                      F\u2010florbetaben PET and cortical amyloid burden and assesses its diagnostic value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 73 patients who underwent\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben PET imaging. Salivary gland uptake (SUVR\n                      <jats:sub>SG<\/jats:sub>\n                      ) was measured and compared with the cortical amyloid burden, severity of dementia, and clinical diagnoses (cognitively normal, mild cognitive impairment, and dementia). Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean SUVR\n                      <jats:sub>SG<\/jats:sub>\n                      was 1.43 \u00b1 0.29, with no significant differences based on the cortical amyloid burden, severity of dementia, or clinical diagnosis. SUVR\n                      <jats:sub>SG<\/jats:sub>\n                      did not correlate with the cortical amyloid burden (\u03c1 = \u22120.103, p &gt; 0.05). The area under the ROC curve and volume under the ROC surface indicated that SUVR\n                      <jats:sub>SG<\/jats:sub>\n                      had poor diagnostic performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Salivary gland uptake on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben PET was not associated with the cortical amyloid burden or clinical stage of AD, and it did not demonstrate diagnostic value. Further research is needed to explore its biological significance and standardization methods.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71199","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:02:01Z","timestamp":1767808921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salivary Gland Uptake on\n                    <sup>18<\/sup>\n                    F\u2010Florbetaben PET Did Not Demonstrate Additional Diagnostic Value for Alzheimer's Disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Hyun Woo","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Korea University Ansan Hospital  Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saim","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Korea University Ansan 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