{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:48:54Z","timestamp":1791564534215,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic Obstructive Pulmonary Diseases (COPD) impose a substantial global health burden, yet the joint impact of arterial stiffness and depression on their incidence remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study analyzed adults aged \u226545 years from the China Health and Retirement Longitudinal Study (2011\u20132018). Participants with baseline COPD or missing data were excluded. Cox proportional hazards models assessed associations, while mediation analysis evaluated bidirectional roles of the estimated pulse wave velocity (ePWV) and 10\u2010item Center for Epidemiologic Studies Depression Scale (CESD\u201010) in new\u2010onset COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 7 years, 718 participants developed COPD. ePWV (HR = 1.11,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and depression (HR = 1.63,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) independently increased risk, with the highest hazard in comorbid cases (HR = 2.17,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). ePWV mediated 1.7% of depression's effect, while depression mediated 4.8% of ePWV's impact (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher ePWV and depressive symptoms were independently associated with incident chronic obstructive pulmonary disease. The observed mediation effects were statistically significant but small in magnitude and should be interpreted as exploratory rather than clinically meaningful. These findings are hypothesis\u2010generating and warrant confirmation using objective measurements and causal study designs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71200","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:29:02Z","timestamp":1768886942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint Association of Arterial Stiffness and Depression With New\u2010Onset Self\u2010Reported Chronic Obstructive Pulmonary Disease Among Elderly Chinese Population"],"prefix":"10.1002","volume":"16","author":[{"given":"Qinqin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Jishuitan Hospital, Capital Medical University  Xicheng District, Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Jishuitan Hospital, Capital Medical University  Xicheng District, Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing P.R. 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