{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:23:14Z","timestamp":1787602994515,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010stroke cognitive impairment (PSCI) is a common complication following a stroke. Recent findings highlight the role of miR\u2010502\u20103p in both vascular and neurodegenerative diseases. However, the role in PSCI remains uncovered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study emphasized the differential expression of miR\u2010502\u20103p and subsequently evaluated the predictive value of miR\u2010502\u20103p expression levels for PSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The study subjects included 112 patients with PSCI and 161 individuals with post\u2010stroke cognitive normality. The relative expression of miR\u2010502\u20103p was calculated by qPCR, while its predictive value for PSCI was assessed via ROC curve. Pearson's correlation coefficient was utilized to analyze the correlation between serum miR\u2010502p\u20103p levels and PSCI. Multivariate logistic regression was used to identify risk factors of PSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum miR\u2010502\u20103p was identified as significantly elevated in the PSCI group. The area under the ROC curve was 0.850, with a sensitivity of 76.79% and a specificity of 77.64%. The miR\u2010502\u20103p level was positively correlated with both NIHSS and mRS scores. In addition, a negative correlation was observed between the miR\u2010502\u20103p level and MoCA score. Elevated miR\u2010502\u20103p and hypertension were identified as independent risk factors for PSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significantly elevated serum miR\u2010502\u20103p was a promising biomarker for the onset of PSCI. Elevated miR\u2010502\u20103p and hypertension were independent risk factors for PSCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71208","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:32:24Z","timestamp":1770708744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of Elevated miR\u2010502\u20103p in Patients With Post\u2010Stroke Cognitive Impairment"],"prefix":"10.1002","volume":"16","author":[{"given":"Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Nursing The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Neuroscience Medical Center, Chongqing No. 13 People's Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Nanjing Lishui District Hospital of Traditional Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1056427"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa\u20102022\u20100017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.08.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040532"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70389"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S465249"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001441"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018789839"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211065917"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201071184\u2010x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207615"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.01.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2505174"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.01.028"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215644"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525\u2010022\u201000319\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2023.10.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1375973"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504704"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010024429"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241279888"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024295"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx090"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15068"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102123"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124936"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201075450\u20106"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","unstructured":"Sharma B. 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