{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:04Z","timestamp":1787602924218,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018764","name":"Semnan University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["2093"],"award-info":[{"award-number":["2093"]}],"id":[{"id":"10.13039\/501100018764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive balance exercises may change corticomotor excitability during the learning process of postural stability control. The primary purpose of the present study was to assess corticomotor excitability corresponding to the peroneus longus muscle under transcranial magnetic stimulation following 6 weeks of progressive balance exercises in individuals with chronic ankle instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible volunteers diagnosed with chronic ankle instability were randomly assigned to either the intervention group or the control group. The intervention group practiced progressive balance exercises every other day for 6 weeks, while the control group continued their daily activities. The corticomotor excitability outcome measures included the active and resting corticomotor thresholds, the motor evoked potential, and the cortical silent period of the peroneus longus muscle, which were measured using an electromyography device under a transcranial magnetic stimulator. The outcome measures were measured in the intervention group before and after progressive balance exercises, and in the control group at baseline and again after a 6\u2010week interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The corticomotor thresholds and cortical silent period of the peroneus longus muscle were significantly decreased within groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt; 0.001;\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.580). In addition, the normalized motor evoked potential of the peroneus longus muscle exhibited a significant increase within groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt; 0.001;\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.265). Interestingly, a significant interaction effect was revealed between the within\u2010group and between\u2010group effects for the corticomotor excitability outcome measures related to the peroneus longus muscle (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt; 0.001;\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.311).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Six weeks of progressive balance exercises significantly increased corticomotor excitability corresponding to the peroneus longus muscle in individuals with chronic ankle instability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71222","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:31:33Z","timestamp":1769758293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corticomotor Excitability Changes Induced by Progressive Balance Exercises in Chronic Ankle Instability: a Randomized Clinical Trial"],"prefix":"10.1002","volume":"16","author":[{"given":"Mahdis","family":"Purzolfi","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, School of Rehabilitation Sciences Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-961X","authenticated-orcid":false,"given":"Cyrus Taghizadeh","family":"Delkhoush","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, School of Rehabilitation Sciences Semnan University of Medical Sciences  Semnan Iran"},{"name":"Neuromuscular Rehabilitation Research Center, Research Institute of Neurosciences Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Mirmohammadkhani","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"1019","article-title":"Immediate Effect of Warm\u2010Up on Single\u2010Leg Balance in Individuals With and Without Functional Ankle Instability","volume":"15","author":"Abalos E.","year":"2022","journal-title":"International Journal of Exercise Science"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.11.056"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2017.6836"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2021.102833"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.08.048"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00505"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1123\/jsr.2023\u20100024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108998.<\/bib"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2024.102910"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2016.6602"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010024\u201006930\u20108"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062\u20106050\u201049.1.14"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.01.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1836082.041"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2016.1207105"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00067.2019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062\u20106050\u2010344\u201018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062\u20106050\u2010447\u201017"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.05.022"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13081209"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108950"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.23937\/2469\u20105718\/1510036"},{"key":"e_1_2_11_24_1","volume-title":"Principles of Neural Science","author":"Kandel E. 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