{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:59Z","timestamp":1787602979473,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To compare the clinical outcomes among various infarct patterns and to investigate the associations between the morphological parameters of contralateral middle cerebral artery (cMCA) M\n                      <jats:sub>1<\/jats:sub>\n                      segment and infarct patterns in ischemic stroke attributed to large vessel occlusion (LVO) in M\n                      <jats:sub>1<\/jats:sub>\n                      segment caused by intracranial atherosclerotic disease (ICAD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with stroke attributed to M\n                      <jats:sub>1<\/jats:sub>\n                      \u2010ICAD\u2010LVO were enrolled. The infarct patterns were categorized into artery\u2010to\u2010artery embolism (AAE), large infarct, borderzone infarct (BZI), and perforating artery infarction (PAI). The morphological parameters of cMCA\u2010M\n                      <jats:sub>1<\/jats:sub>\n                      segment included proximal and distal diameter, arc, and chord length. The tortuosity index of cMCA\u2010M\n                      <jats:sub>1<\/jats:sub>\n                      segment was calculated by (arc length\/chord length\u00a0\u2212\u00a01)\u00a0\u00d7\u00a0100%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 171 participants were enrolled. Compared to AAE, the risk of poor outcome increased in BZI (odds ratio [OR]\u00a0=\u00a05.51, 95% confidence interval [CI]\u00a0=\u00a01.71\u201317.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) and large infarct (OR\u00a0=\u00a010.92, 95% CI\u00a0=\u00a02.01\u201359.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006) and was comparable in PAI. The tortuosity index (OR\u00a0=\u00a02.85, 95% CI\u00a0=\u00a01.13\u20137.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.026) and arc length (OR\u00a0=\u00a02.47, 95% CI\u00a0=\u00a01.02\u20135.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.045) significantly increased in BZI than other three patterns. Participants other than BZI were categorized into large infarct (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032) and non\u2010large\u2010infarct (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046) groups, and the proximal diameter (OR\u00a0=\u00a00.22, 95% CI\u00a0=\u00a00.07\u20130.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), arc length (OR\u00a0=\u00a00.88, 95% CI\u00a0=\u00a00.78\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018), and chord length (OR\u00a0=\u00a00.87, 95% CI\u00a0=\u00a00.77\u20130.995,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042) were associated with large infarct.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      For patients with M\n                      <jats:sub>1<\/jats:sub>\n                      \u2010ICAD\u2010LVO, large infarct and BZI had poorer outcomes than PAI and AAE. The cMCA\u2010M\n                      <jats:sub>1<\/jats:sub>\n                      segment with elevated tortuosity and arc length was associated with BZI, whereas a thin and short M\n                      <jats:sub>1<\/jats:sub>\n                      segment was correlated with large infarct in patients with a less tortuous cMCA trunk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71226","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:33:48Z","timestamp":1769592828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Correlations of Clinical Outcomes and Vascular Morphology With Infarct Patterns in Middle Cerebral Arterial Occlusion"],"prefix":"10.1002","volume":"16","author":[{"given":"ZhiRong","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Siyang Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShaoQing","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology Siyang Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaNan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Siyang Kangda Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Siyang Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingWei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Siyang Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-7408","authenticated-orcid":false,"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532465"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001127"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.01.031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318281ccc2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.203"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2023.00185"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011731"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20942609"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025732"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47281-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-009-0151-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.8.1051"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213379"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013489"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0247"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12525"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013736"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12497"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.672741"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189999.19948.14"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2021.01375"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.1070"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032856"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027661"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx352"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599464"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa563"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90953-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017673"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214403"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085831"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4280410"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.12829"},{"issue":"20","key":"e_1_2_9_38_1","first-page":"S145","article-title":"Intracranial Atherosclerotic Disease: Current Concepts in Medical and Surgical Management","volume":"97","author":"Tekle W. G.","year":"2021","journal-title":"Neurology"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001526"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104504"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015172"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027708"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020046"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305159"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002102"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1129503"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000202590.75972.39"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001467"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118191"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:46:04Z","timestamp":1787600764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/brb3.71226"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71226","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.71226\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71226\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71226\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71226"}}