{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:39Z","timestamp":1787602959957,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Comparison of recorded diagnoses of multiple sclerosis (MS) and related disorders and disease\u2010modifying therapies (DMTs) in The Danish Multiple Sclerosis Registry (DMSR) with other nationwide health registries. The aim of the study is to describe and compare information on diagnoses of MS and related disorders and treatments with DMTs available in three national registries, highlighting the key differences relevant to MS research and providing insight for researchers for their choice of data source(s) suitable for their study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>DMSR is a disease registry encompassing information on persons with MS and related disorders. The Danish National Patient Registry (DNPR) is a registry of activities at Danish hospitals. The Danish National Hospital Medication Registry (DNHMR) contains information on in\u2010hospital prescription medications. The population comprised all persons in DMSR in 2023 who were alive or born after and residing in Denmark on January 1, 1995 (N = 26,474). For this population, we identified DNPR contacts with diagnoses of MS or related disorders and initiated DMTs in DNHMR. Diagnostic and demographic characteristics were reported as recorded in DMSR for the total population, and the subset included in DMSR but not in DNPR. Characteristics of the part of the population identified in DNPR were reported as recorded in DNPR. We calculated the proportions of DMT treatments in DMSR identified in DNHMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 26,474 persons, 23,857 (90.1%) were recorded with a diagnosis of MS or a related disorder in DNPR. Most (86.6%) of the 2617 persons not identified in DNPR were diagnosed before 1995. The proportion of persons with MS recorded without specification of the disease phenotype was 23.5% in the DMSR and 76.2% in the DNPR. After 2005, only 1.8% of persons with MS were recorded with an unspecified phenotype in DMSR. Of a total of 18,168 initiated DMT treatments in DMSR, 7230 (39.8%) were identified in DNHMR, with proportions ranging from 0.0% (mitoxantrone) to 88.5% (ocrelizumab).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DMSR is suitable for disease\u2010specific research addressing treatment efficacy, disease development, and long\u2010term outcomes. In contrast, DNPR is well suited for broad epidemiological studies involving various health conditions and hospital utilization. The DNHMR will, when matured, be useful for studies involving medical treatment and comedication. However, as each registry has limitations, for most studies the best approach will be combining registries, depending on the research question.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71235","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:44:01Z","timestamp":1770795841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnoses of Multiple Sclerosis and Related Disorders and Disease\u2010Modifying Therapies: A Comparison of the Danish Multiple Sclerosis Registry With Other Danish Health Registries"],"prefix":"10.1002","volume":"16","author":[{"given":"Hanna","family":"Joensen","sequence":"first","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Framke","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Pontieri","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Magyari","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Glostrup Denmark"},{"name":"Danish Multiple Sclerosis Center, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500418"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12424"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2015.02.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S314959"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1921"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99500"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S179083"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_12_11_1","unstructured":"The Danish Health Data Authority. n.d. \u201cDokumentation af registre (Documentation of registries).\u201d Accessed December 16 2024.https:\/\/www.esundhed.dk\/Dokumentation\/DocumentationExtended?id=5."},{"key":"e_1_2_12_12_1","unstructured":"The Danish Health Data Authority. n.d. \u201cSygehusmedicinregisteret (Danish National Hospital Medication Register).\u201d Accessed December 16 2024https:\/\/sundhedsdatastyrelsen.dk\/data\u2010og\u2010registre\/nationale\u2010sundhedsregistre\/sygehusmedicinregisteret."}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:46:31Z","timestamp":1787600791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/brb3.71235"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71235","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.71235\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71235\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71235\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71235\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71235"}}