{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:38Z","timestamp":1787602958199,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723653"],"award-info":[{"award-number":["2022M723653"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rotator cuff tendinopathy (RCT) is a major contributor to over 30 million surgeries which are conducted to treat shoulder overuse injuries worldwide annually. Accumulating evidence indicates that neuropsychiatric disorders (ND) share pathogenic pathways with tendinopathy. However, unclarified causal relationships between these two disease spectra undermine the individualized design of treatment strategies benefiting patients with ND while minimizing the RCT risk. We aimed to unveil whether ND were genetically associated with increased RCT occurrence by conducting a two\u2010sample Mendelian randomization (MR) algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genome\u2010wide association studies (GWAS) data of attention deficit\/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD), post\u2010traumatic stress disorder (PTSD), schizophrenia (SCZ), and RCT patients of European ancestry were retrieved for bidirectional two\u2010sample Mendelian randomization (MR) analyses to establish causal relationships among these eight main types of ND and RCT. To detect false positive findings, MR\u2010Egger, weighted median and causal analysis using summary effect estimates (CAUSE) were employed as sensitivity tests. Body shape, lifestyle, and socioeconomic parameters were adjusted as mediators in multivariable MR to validate the robustness of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariable MR revealed that genetic predisposition to ADHD (odds ratio [OR] 1.14, 95% confidence interval [CI] 1.05\u20131.24,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and PTSD (OR 2.23, 95% CI 1.75\u20132.84,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) significantly increased the RCT risk. MDD showed a similar association (OR 1.21, 95% CI 1.06\u20131.38,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), which was attenuated after confounder adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.78). Multivariable MR confirmed ADHD (OR 1.09, 95% CI 1.01\u20131.18,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) and PTSD (OR 2.00, 95% CI 1.41\u20132.82,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) as robust causal factors for RCT after adjusting for anthropometric, lifestyle, physical activity, and socioeconomic confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study sheds new light on the need for early screening, targeted overuse injury prevention, and specialized clinical interventions to alleviate the RCT burden in ADHD and PTSD populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71246","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:43:56Z","timestamp":1769762636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding Causal Associations Between Neuropsychiatric Disorders and Rotator Cuff Tendinopathy: A Two\u2010Sample Mendelian Randomization Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Weizhe","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Joint Surgery, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Mental Health Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puyi","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-07047-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb02570.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12402\u2010018\u20100252\u20102"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2004.09.022"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.910824"},{"key":"e_1_2_12_7_1","first-page":"1","article-title":"Posttraumatic Stress Disorder and Risk of Selected Autoimmune Diseases among US Military Personnel","volume":"20","author":"Bookwalter D. B.","year":"2020","journal-title":"BMC Psychiatry [Electronic Resource]"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2019.00013"},{"key":"e_1_2_12_9_1","first-page":"1","article-title":"Tendon Healing Is Adversely Affected by Low\u2010Grade Inflammation","volume":"16","author":"Chisari E.","year":"2021","journal-title":"Journal of Orthopaedic Surgery"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.08.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62129-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818809831"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046\u20103758.17.2000115"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035883"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem\u20102022\u2010001326"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00992.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2022.06.040"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01517-7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2019.05.014"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.07.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9156"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1994.tb05932.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2016.09.032"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201002094\u20107"},{"issue":"2","key":"e_1_2_12_28_1","first-page":"238","article-title":"Current Opinions on Tendinopathy","volume":"10","author":"Kaux J. F.","year":"2011","journal-title":"Journal of Sports Science and Medicine"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.11.007"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.t01-1-26901.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.09.006"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2020.03.046"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei139"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ptsp.2019.01.003"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201002869\u20100"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102359"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7525.1124"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046\u20103758.612.BJR\u20102017\u20100112.R1"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0631-4"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.026857"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.2530"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17671"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-154"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210394459"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.041"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00390\u20106"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635\u2010201106000\u201000007"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199204854.003.2604"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2005.10.014"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801218"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2022.03.007"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515580790"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.21926\/obm.neurobiol.2301155"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101313"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02729-3"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010060619\u2010022943"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/ssmith"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.13800"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2018.03.003"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00056-9"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.12.959"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102021\u2010104858"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185490"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2005.05.017"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01165-1"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2022-001494"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-022-00525-2"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2020.102173"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100090\u20103"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.2694"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00444"},{"key":"e_1_2_12_77_1","first-page":"370","article-title":"Correlation Between INTERLEUKIN\u20101b, Interleukin\u20106, Tumor Necrosis Factor\u2010a and Attention Deficit Hyperactivity Disorder","volume":"27","author":"Xiang\u2010Dong P.","year":"2012","journal-title":"Maternal and Child Health Care of China"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010025\u201006846\u20104"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:47:19Z","timestamp":1787600839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/brb3.71246"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71246","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.71246\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.71246\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71246"}}