{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:52Z","timestamp":1786977172304,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Edaravone dexborneol is a neuroprotective agent combining the free\u2010radical scavenging properties of edaravone and the anti\u2010inflammatory, blood\u2013brain barrier\u2013modulating effects of dexborneol. While international trials have demonstrated favorable safety and potential clinical benefit, data in Filipino patients remain lacking. This study evaluated the real\u2010world safety and tolerability of edaravone dexborneol among Filipino patients with acute ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center, open\u2010label, single\u2010arm, prospective study conducted under a compassionate\u2010use program. Patients aged 18\u201380 years with clinically confirmed acute ischemic stroke within 48 h of onset received edaravone dexborneol (30\u00a0mg edaravone + 7.5\u00a0mg dexborneol) twice daily for 14 days. Safety monitoring continued until Day 20. Treatment\u2010emergent adverse events (TEAEs) and serious adverse events (SAEs) were classified using the International Council for Harmonisation (ICH E2A) criteria, and causality was assessed using the World Health Organization\u2013Uppsala Monitoring Centre (WHO\u2013UMC) categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven of 29 enrolled patients completed the 14\u2010day regimen. Mean age was 55.7 \u00b1 12.8 years; 66.7% were male. Overall, 15 patients (55.6%) experienced at least one TEAE, most commonly headache (29.6%), which occurred on Day 0 and resolved within 0.7 \u00b1 1.2 days. Elevated liver enzymes were observed in 25.9% for aspartate transaminase (AST) as well as for alanine aminotransferase (ALT), generally mild and self\u2010limited. One patient developed both moderate transaminitis and acute kidney injury, attributed to concurrent antituberculosis therapy rather than the study drug. No treatment discontinuations, life\u2010threatening reactions, or deaths occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Edaravone dexborneol demonstrated a favorable safety profile in Filipino patients with acute ischemic stroke, with adverse events (AE) predominantly mild, transient, and reversible. These real\u2010world findings align with international data and support their potential incorporation into acute stroke management pathways in the Philippines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71272","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:35:08Z","timestamp":1773135308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective Open\u2010Label Safety Study of Edaravone Dexborneol in Filipino Patients With Acute Ischemic Stroke"],"prefix":"10.1002","volume":"16","author":[{"given":"Zenyros Faith","family":"Sabellano","sequence":"first","affiliation":[{"name":"Department of Neurology Jose R. Reyes Memorial Medical Center, National Specialty Center for Brain and Spine Care  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Bonifacio","family":"Pedregosa","sequence":"additional","affiliation":[{"name":"Department of Neurology Jose R. Reyes Memorial Medical Center, National Specialty Center for Brain and Spine Care  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Kristoffer","family":"Batino","sequence":"additional","affiliation":[{"name":"Department of Neurology Baguio General Hospital and Medical Center  Baguio Benguet Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Neurology Jose R. Reyes Memorial Medical Center, National Specialty Center for Brain and Spine Care  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/808460"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00081"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401117"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007230.pub2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000442015.53336.12"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199812000-00004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/157489006775244191"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351753"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"325","article-title":"Thrombolysis in Ischaemic Stroke in Rural Northeast Thailand","volume":"21","author":"Kongbunkiat K.","year":"2016","journal-title":"Neurology Asia"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.844734"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.11.029"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.04.001"},{"key":"e_1_2_12_14_1","first-page":"36","article-title":"Edaravone\u2013Citicoline Comparative Study in Acute Ischemic Stroke (ECCS\u2010AIS)","volume":"60","author":"Mitta M.","year":"2012","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_12_15_1","unstructured":"Nanjing Simcere Dongyuan Pharmaceutical Co. n.d.\u2010a. \u201cSanbexin: Edaravone and Dexborneol Concentrated Solution for Injection.\u201dSimcere.https:\/\/en.simcere.com\/pro\/detail.aspx?mtt=63."},{"key":"e_1_2_12_16_1","volume-title":"Bicun: Edaravone Injection","author":"Nanjing Simcere Dongyuan Pharmaceutical Co"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_12_18_1","first-page":"11","article-title":"Prevalence of Stroke: Community Survey","volume":"9","author":"Navarro J. C.","year":"2005","journal-title":"Philippine Journal of Neurology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12287"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069318"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2013.15.3.128"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354162"},{"key":"e_1_2_12_23_1","unstructured":"Santos T. G.2016.Free Medicine Available for Stroke Victims. 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